Gene

isl1a

ID
ZDB-GENE-980526-112
Name
ISL LIM homeobox 1a
Symbol
isl1a Nomenclature History
Previous Names
  • Isl-1 (1)
  • isl1
  • islet-1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including atrial cardiac muscle cell differentiation; neuron differentiation; and pancreas development. Localizes to nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Is expressed in several structures, including mesoderm; nervous system; neural rod; pancreatic system; and pericardial region. Orthologous to human ISL1 (ISL LIM homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
300 figures from 215 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
33 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With isl1a Human Ortholog
No data available
Associated With isl1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR001781 Zinc finger, LIM-type
Domain IPR047244 Insulin gene enhancer protein ISL-1/2-like, LIM domain1
Family IPR047169 Insulin gene enhancer protein ISL-1/2-like
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Homeobox, conserved site Homeodomain Insulin gene enhancer protein ISL-1/2-like Insulin gene enhancer protein ISL-1/2-like, LIM domain1 Zinc finger, LIM-type
UniProtKB:A0A8M2BCL0 348
UniProtKB:A0A8M9PJN3 257
UniProtKB:P53405 349
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA isl1-201 (1) Ensembl 2,303 nt
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-isl monoclonal IgG1 Mouse
  • IHC
Developmental Studies Hybridoma Bank
26
Ab5-isl1 monoclonal IgG1 Mouse
  • IHC
Developmental Studies Hybridoma Bank
2
Ab1-isl1 polyclonal IgG Rabbit
  • IHC
2
Ab2-isl monoclonal IgG2b Mouse
  • IHC
Developmental Studies Hybridoma Bank
142
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations