Gene

isl1a

ID
ZDB-GENE-980526-112
Name
ISL LIM homeobox 1a
Symbol
isl1a Nomenclature History
Previous Names
  • Isl-1 (1)
  • isl1
  • islet-1
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in sinoatrial node cell development. Acts upstream of or within several processes, including atrial cardiac muscle cell differentiation; neuron differentiation; and pancreas development. Located in nucleus. Is expressed in several structures, including mesoderm; nervous system; pancreatic system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
284 figures from 203 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
33 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With isl1a Human Ortholog
No data available
Associated With isl1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR001781 Zinc finger, LIM-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Zinc finger, LIM-type
UniProtKB:P53405 349
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-isl monoclonal IgG1 Mouse
  • IHC
Developmental Studies Hybridoma Bank
25
Ab5-isl1 monoclonal IgG1 Mouse
  • IHC
Developmental Studies Hybridoma Bank
2
Ab1-isl1 polyclonal IgG Rabbit
  • IHC
2
Ab2-isl monoclonal IgG2b Mouse
  • IHC
Developmental Studies Hybridoma Bank
125
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations