Gene
sfrp1a
- ID
- ZDB-GENE-040310-5
- Name
- secreted frizzled-related protein 1a
- Symbol
- sfrp1a Nomenclature History
- Previous Names
-
- sfrp1
- wu:fd19b09
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable Wnt-protein binding activity. Acts upstream of or within camera-type eye morphogenesis and positive regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Orthologous to human SFRP1 (secreted frizzled related protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010068Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la010601Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024933Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024934Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa33610 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| w217Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| w222Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sfrp1a | (3) | |
| MO1-sfrp1a | N/A | (2) |
| MO2-sfrp1a | N/A | Lu et al., 2011 |
| MO3-sfrp1a | N/A | Holly et al., 2014 |
| MO4-sfrp1a | N/A | Holly et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001134 | Netrin domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR020067 | Frizzled domain |
| Family | IPR015526 | Frizzled/secreted frizzled-related protein |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR036790 | Frizzled cysteine-rich domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Netrin domain | Netrin module, non-TIMP type | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2K9 | InterPro | 296 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sfrp1a-201
(1)
|
Ensembl | 1,577 nt | ||
| mRNA |
sfrp1a-202
(1)
|
Ensembl | 524 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-202K21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-264H3 | ZFIN Curated Data | |
| Encodes | EST | fd19b09 | ||
| Encodes | cDNA | MGC:123001 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205585 (1) | 1530 nt | ||
| Genomic | GenBank:BX000481 (1) | 163926 nt | ||
| Polypeptide | UniProtKB:Q7T2K9 (1) | 296 aa |
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
- Ye, Z., Kimelman, D. (2020) hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development (Cambridge, England). 147(22):
- Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
- Lush, M.E., Diaz, D.C., Koenecke, N., Baek, S., Boldt, H., St Peter, M.K., Gaitan-Escudero, T., Romero-Carvajal, A., Busch-Nentwich, E.M., Perera, A.G., Hall, K.E., Peak, A., Haug, J.S., Piotrowski, T. (2019) scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. eLIFE. 8:
- Obermann, J., Wagner, F., Kociaj, A., Zambusi, A., Ninkovic, J., Hauck, S.M., Chapouton, P. (2019) The Surface Proteome of Adult Neural Stem Cells in Zebrafish Unveils Long-Range Cell-Cell Connections and Age-Related Changes in Responsiveness to IGF. Stem Cell Reports. 12(2):258-273
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