Gene

dld

ID
ZDB-GENE-990415-47
Name
deltaD
Symbol
dld Nomenclature History
Previous Names
  • aei
  • after eight
  • sc:d0402
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits PDZ domain binding activity. Involved in several processes, including animal organ development; lateral inhibition; and regulation of hematopoietic stem cell differentiation. Localizes to perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
Genome Resources
Note
None
Expression
All Expression Data
84 figures from 67 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 15 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dld Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures 618709
Associated With dld Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR011651 Notch ligand, N-terminal domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Notch ligand, N-terminal domain
UniProtKB:F1QFH0 717
UniProtKB:A1L1P2 717
UniProtKB:Q8UWJ4 717
UniProtKB:A4JYS1 717
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dld monoclonal IgG1 Mouse
  • IHC
  • WB
Abcam plc
19
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations