Gene

dld

ID

ZDB-GENE-990415-47

Name

deltaD

Symbol

dld Nomenclature History

Previous Names

aei
after eight
sc:d0402

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Exhibits PDZ domain binding activity. Involved in several processes, including animal organ development; lateral inhibition; and regulation of hematopoietic stem cell differentiation. Localizes to perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

88 figures from 70 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 22 figures from 15 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dld Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	618709

Associated With dld Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001774	Delta/Serrate/lag-2 (DSL) protein
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR011651	Notch ligand, N-terminal domain
Family	IPR050906	Notch signaling pathway
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site