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ZIRC
ZFIN ID: ZDB-GENE-990415-47
Gene Name: deltaD
Gene Symbol: dld    Nomenclature History

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Previous Names: aei, after eight, sc:d0402

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits PDZ domain binding activity. Involved in several processes, including animal organ development; lateral inhibition; and regulation of hematopoietic stem cell differentiation. Localizes to the perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including gut; mesoderm; nervous system; presumptive mesoderm; and tail bud. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
Genome Resources: Alliance (1),  Gene:30138 (1),  Ensembl(GRCz11):ENSDARG00000020219 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dld_unspecified Unspecified Unknown Unknown
sa15390 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22208 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45480 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tg22a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg249 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm223 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tr233 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dld N/A 3
    MO2-dld N/A 14
    MO3-dld N/A 3
    MO4-dld N/A 1
    DISEASE ASSOCIATED WITH dld HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures 618709
    DISEASE ASSOCIATED WITH dld VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right asymmetry in lateral mesoderm (more)
    Cellular Component cytoplasm (more)
    Molecular Function PDZ domain binding (more)
    GO Terms (all 30)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dld-201 (1)    Ensembl 3339
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-dld monoclonal IgG1 Mouse IHC, WB Abcam plc
    18
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dld
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.2dld:dld-mCherry) dld dldmCherry Danio rerio 1 3
    Tg(-1.3dld:GFP) dld GFP Danio rerio 1 3
    Tg(-1.8dld:GFP) dld GFP Danio rerio 1 3
    Tg(-3.5dld:GFP) dld GFP Danio rerio 1 5
    Tg(-6dld:GFP) dld GFP Danio rerio 1 5
    Tg(dld:dld-MYC) dld dld Danio rerio 1 3
    Tg(dld:GAL4) dld GAL4 Danio rerio 1 11
    Tg1(dld:GFP) dld GFP Danio rerio 1 3
    Tg2(dld:GFP) dld GFP Danio rerio 1 3
    Tg3(dld:GFP) dld GFP Danio rerio 1 3
    Tg4(dld:GFP) dld GFP Danio rerio 1 4
    Tg5(dld:GFP) dld GFP Danio rerio 1 3
    Tg6(dld:GFP) dld GFP Danio rerio 1 3
    Tg7(dld.7:GFP) dld GFP Danio rerio 1 4
    Tg8(dld:GFP) dld GFP Danio rerio 1 4
    Tg9(dld:GFP) dld GFP Danio rerio 1 3
    Tg10(dld:GFP) dld GFP Danio rerio 1 4
    TgBAC(dld:dld-Venus) dld dldVenus Danio rerio 2 2
    MARKER RELATIONSHIPS
    dld Contained in: [Fosmid] CH1073-241D9 (1) (order this)
    dld Encodes: [cDNA] cssl:d402 (1), MGC:158216 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130955 (1) 3377 bp
    Genomic GenBank:CU855920 (1) 41907 bp
    Select Tool
    Polypeptide UniProtKB:A1L1P2 (1) 717 aa
    Sequence Clusters UniGene:75102 (1)
    Sequence Information (all 20)
    ORTHOLOGY for dld ( Chr: 13 )
    CITATIONS (216)