FIGURE

Fig. S6

ID
ZDB-FIG-150922-1
Publication
Moreno-Ayala et al., 2015 - PIAS-like protein Zimp7 is required for the restriction of the Zebrafish organizer and mesoderm development
Other Figures
All Figure Page
Back to All Figure Page
Fig. S6

Supplementary materialSupplementary Figure 6 (A-B) Changes of Zimp7 activity do not compensate variations in Nodal activity. (A) Injection of 3 ng of the oep MO, which decreases the expression of the Nodal-signaling co-receptor Oep, produces characteristic Nodal loss-of-function phenotypes (classified according to Kapp et al). The reduction of Zimp7 activity by co-injecting the oep MO with 4 ng of the zimp7-sp MO does not significantly affect the distribution of phenotypes. (B) Injection of 2pg of the sqt mRNA produces dorsalizations that are not alleviated by the co-injection of 80 or 120 pg of the zimp7 mRNA. (C) Injection of 2 ng of a chd MO previously used to increase BMP activity produces ventralizations, which are not rescued by a reduction of Zimp7 activity with 8 ng of the zimp7-sp MO. Morpholinos were coinjected with p53 MO to score the embryos for phenotype at 30hpf.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-15

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 403(1), Moreno-Ayala, R., Schnabel, D., Salas-Vidal, E., LomelĂ­, H., PIAS-like protein Zimp7 is required for the restriction of the Zebrafish organizer and mesoderm development, 89-100, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.