ZFIN Image: Moreno-Ayala et al., 2015, Fig. S6

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Figure Caption

Fig. S6

Supplementary materialSupplementary Figure 6 (A-B) Changes of Zimp7 activity do not compensate variations in Nodal activity. (A) Injection of 3 ng of the oep MO, which decreases the expression of the Nodal-signaling co-receptor Oep, produces characteristic Nodal loss-of-function phenotypes (classified according to Kapp et al). The reduction of Zimp7 activity by co-injecting the oep MO with 4 ng of the zimp7-sp MO does not significantly affect the distribution of phenotypes. (B) Injection of 2pg of the sqt mRNA produces dorsalizations that are not alleviated by the co-injection of 80 or 120 pg of the zimp7 mRNA. (C) Injection of 2 ng of a chd MO previously used to increase BMP activity produces ventralizations, which are not rescued by a reduction of Zimp7 activity with 8 ng of the zimp7-sp MO. Morpholinos were coinjected with p53 MO to score the embryos for phenotype at 30hpf.

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 403(1), Moreno-Ayala, R., Schnabel, D., Salas-Vidal, E., Lomelí, H., PIAS-like protein Zimp7 is required for the restriction of the Zebrafish organizer and mesoderm development, 89-100, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.