FIGURE

Fig. 7

ID

ZDB-FIG-130730-26

Publication

van der Vaart et al., 2013 - Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system

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Fig. 7

qPCR analysis of the response of myd88^-/- and wild-type embryos to M. marinum infection.
Expression of il1b, tnfa, il8, cxcl-c1c, mmp9 and ifnphi1 was analyzed by qPCR in M. marinum Mma20-infected wild-type (Wt) and mutant (Mu) embryos. RNA samples from M. marinum-infected embryos (inf) and uninfected controls were taken at 4 dpi. Each data point represents an individual embryo and lines indicate the mean relative expression level, with values for uninfected wild type set at 1. Significant differences were calculated by one-way ANOVA with Tukey?s multiple comparison method as a post-hoc test; *P<0.05, ***P<0.001; ns, not significant.

Expression Data

Genes:	cxcl8a cxcl18b ifnphi1 il1b mmp9 tnfa (all 6)
Fish:	WT myd88^{hu3568/hu3568} (AB)
Condition:	bacterial treatment: Mycobacterium marinum
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	myd88^{hu3568/hu3568} (AB)
Condition:	bacterial treatment: Mycobacterium marinum
Observed In:	activation of innate immune response
Stage:	Day 4

Phenotype Detail

Acknowledgments

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