FIGURE

Fig. 1

ID

ZDB-FIG-130510-8

Publication

Münch et al., 2013 - Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration

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Fig. 1

Notch signalling is activated during fin regeneration. (A) qPCR analysis of notch1b, lfng, her6 and her15 mRNA in regenerating fins at 3 dpa relative to expression in non-amputated fins (0 dpa). ^*P<0.05, ^**P<0.01. (B-F) Whole-mount in situ hybridization in 2 dpa fins for jag1b (B), notch1b (C), lfng (D), her6 (E) and her15 (F), showing Notch pathway activation within the blastema (arrowheads). (G) Scheme of a 3 dpa fin section, indicating the two regions within the regenerate: the blastema (b) and the differentiation zone (dz). Green indicates regenerating fin rays. (H-J) In situ hybridization on 3 dpa fin sections for jag1b (H), lfng (I) and her6 (J) reveals Notch pathway activation in the blastema (b, arrowhead), but weak or no gene expression within the dz (arrow). Scale bars: 100 μm in C,F; 10 μm in J. Broken lines mark amputation plane.

Expression Data

Genes:	her6 her15.2 jag1b lfng notch1b
Fish:	WT
Condition:	physical alteration: anatomical structure
Anatomical Terms:	blastema regenerating fin
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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