Gene
her6
- ID
- ZDB-GENE-980526-144
- Name
- hairy-related 6
- Symbol
- her6 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including Notch signaling pathway; regionalization; and thalamus development. Predicted to be active in nucleus. Is expressed in several structures, including anterior neural keel; mesoderm; nervous system; neuronal stem cell; and pectoral fin. Orthologous to human HES1 (hes family bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 61 figures from 44 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb129 (41 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Coolen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| co3005 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| el633 | Allele with one deletion | Unknown | Frameshift | TALEN | |
| sa59 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa20748 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa38559 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| umc301Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-her6 | Soto et al., 2020 | |
| CRISPR2-her6 | Sánchez-Iranzo et al., 2022 | |
| CRISPR3-her6 | Sánchez-Iranzo et al., 2022 | |
| CRISPR4-her6 | (2) | |
| CRISPR5-her6 | (2) | |
| MO1-her6 | N/A | (4) |
| MO2-her6 | N/A | Coolen et al., 2012 |
| MO3-her6 | N/A | (2) |
| TALEN1-her6 | Askary et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Hairy and Enhancer of Split/HEY-related | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6PBX3 | InterPro | 270 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(her6-HNF1-Mmu.Fos:GFP) |
|
| 2 | (3) | |
| Tg(her6:mCherry) |
|
| 1 | Kraus et al., 2022 | |
| Tg(her6-Mmu.Fos:GFP) |
|
| 4 | (2) | |
| Tg(her6-RBPJ-Mmu.Fos:GFP) |
|
| 2 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-111K7 | ZFIN Curated Data | |
| Encodes | EST | cb129 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:73203 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131079 (1) | 1376 nt | ||
| Genomic | GenBank:BX950188 (1) | 260558 nt | ||
| Polypeptide | UniProtKB:Q6PBX3 (1) | 270 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Chen, Y.C., Hsieh, F.Y., Chang, C.W., Sun, M.Q., Cheng, Y.C. (2024) Temporal and Spatial Variations in Zebrafish Hairy/E(spl) Gene Expression in Response to Mib1-Mediated Notch Signaling During Neurodevelopment. International Journal of Molecular Sciences. 25(17):
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Fleischhauer, L., López-Delgado, A.C., Geurtzen, K., Knopf, F. (2023) Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling. Frontiers in endocrinology. 14:11223511122351
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Luo, L., Jia, W., Zhang, Y., Guo, Y., Zhu, J., Li, C. (2023) Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway. Discovery medicine. 35:144156144-156
- Veen, K., Krylov, A., Yu, S., He, J., Boyd, P., Hyde, D.R., Mantamadiotis, T., Cheng, L.Y., Jusuf, P.R. (2023) Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genetics. 19:e1011010e1011010
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Ha, J., Kim, B.S., Min, B., Nam, J., Lee, J.G., Lee, M., Yoon, B.H., Choi, Y.H., Im, I., Park, J.S., Choi, H., Baek, A., Cho, S.M., Lee, M.O., Nam, K.H., Mun, J.Y., Kim, M., Kim, S.Y., Son, M.Y., Kang, Y.K., Lee, J.S., Kim, J.K., Kim, J. (2022) Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Science advances. 8:eabk1239
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
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