FIGURE

Fig. S5

ID

ZDB-FIG-130510-18

Publication

Münch et al., 2013 - Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration

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Fig. S5

NICD overexpression leads to increased blastema width and increases EGFP expression in Tg(UAS:NICD);Et33-mi60A fish. (A,B) Immunohistochemistry for Myc does not label wild-type fin sections (A), whereas Myc-NICD expression is detected in peripheral cells, most likely osteoblasts, and cells within the ray in the fin stump of Tg(UAS:NICD) fish (B). (C) Mean blastema width of wild-type and Tg(UAS:NICD) fin sections at 5 dpa. ***P<0.05. (D-E′) Tg(UAS:NICD) fish were crossed with Et33-mi60A fish and the Tg(UAS:NICD);Tg Et33-mi60A fish were exposed to a series of heat shocks during 5 days of regeneration. EGFP expression is increased in Tg(UAS:NICD);ET33-mi60A fish at 5 dpa (E9) compared with ET33-mi60A fish. Scale bars: 10 μm. Broken lines mark the amputation plane.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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