Gene
notch1b
- ID
- ZDB-GENE-990415-183
- Name
- notch receptor 1b
- Symbol
- notch1b Nomenclature History
- Previous Names
-
- etID309871.5 (1)
- wu:fc55e11
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and signaling receptor activity. Involved in Notch signaling pathway. Acts upstream of or within several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to be located in membrane and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 175 figures from 118 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu523 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Adams-Oliver syndrome | Alliance | Adams-Oliver syndrome 5 | 616028 |
| aortic valve disease 1 | Alliance | Aortic valve disease 1 | 109730 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000800 | Notch domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR010660 | Notch, NOD domain |
| Domain | IPR011656 | Notch, NODP domain |
| Domain | IPR024600 | Notch, C-terminal |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR008297 | Notch |
| Family | IPR022362 | Neurogenic locus notch homolog protein 1 |
| Family | IPR051355 | Notch and Slit guidance protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR035993 | Notch-like domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Neurogenic locus notch homolog protein 1 | Notch | NOTCH1 EGF-like calcium-binding domain | Notch and Slit guidance protein | Notch, C-terminal | Notch domain | Notch-like domain superfamily | Notch, NOD domain | Notch, NODP domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0PGH6 | InterPro | 2465 | |||||||||||||||||
| UniProtKB:A0A8M2BFY6 | InterPro | 2482 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
notch1b-201
(1)
|
Ensembl | 7,781 nt | ||
| mRNA |
notch1b-202
(1)
|
Ensembl | 7,824 nt | ||
| mRNA |
notch1b-203
(1)
|
Ensembl | 2,314 nt |
Interactions and Pathways
Plasmids
No data available