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Gene

notch1b

ID
ZDB-GENE-990415-183
Name
notch receptor 1b
Symbol
notch1b Nomenclature History
Previous Names
  • etID309871.5 (1)
  • wu:fc55e11
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and signaling receptor activity. Involved in Notch signaling pathway. Acts upstream of or within several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
150 figures from 102 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With notch1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Adams-Oliver syndrome Alliance Adams-Oliver syndrome 5 616028
aortic valve disease 1 Alliance Aortic valve disease 1 109730
Associated With notch1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000800 Notch domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR010660 Notch, NOD domain
Domain IPR011656 Notch, NODP domain
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR024600 Domain of unknown function DUF3454, notch
Family IPR008297 Notch
Family IPR022362 Neurogenic locus Notch 1
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR035993 Notch-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Domain of unknown function DUF3454, notch EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Neurogenic locus Notch 1 Notch Notch domain Notch-like domain superfamily Notch, NOD domain Notch, NODP domain
UniProtKB:F1QCA7 2465
UniProtKB:O42372 638
UniProtKB:A0PGH6 2465
UniProtKB:A5WUN6 2436
UniProtKB:O93616 683
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations