ZFIN ID: ZDB-GENE-990415-183
Gene Name: notch receptor 1b
Gene Symbol: notch1b    Nomenclature History

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Previous Names: etID309871.5 (1), wu:fc55e11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to localize to the plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Orthologous to human NOTCH1 (notch receptor 1).
Genome Resources: Alliance (1),  Gene:794892 (1),  Ensembl(GRCz11):ENSDARG00000052094 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1187 Point Mutation Unknown Splice Site ENU
sa11236 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26616 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26617 Point Mutation Unknown Splice Site ENU
    zf2046 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-notch1b 1
    CRISPR2-notch1b 1
    MO1-notch1b N/A 3
    MO2-notch1b N/A 12
    MO3-notch1b N/A 1
    MO4-notch1b N/A 3
    MO5-notch1b N/A 1
    MO6-notch1b N/A 3
    MO7-notch1b N/A 2
    DISEASE ASSOCIATED WITH notch1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome Alliance Adams-Oliver syndrome 5 616028
    aortic valve disease 1 Alliance Aortic valve disease 1 109730
    DISEASE ASSOCIATED WITH notch1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR000800 Notch domain
    Domain IPR001881 EGF-like calcium-binding domain
    Repeat IPR002110 Ankyrin repeat
    Family IPR008297 Notch
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Domain IPR010660 Notch, NOD domain
    Domain IPR011656 Notch, NODP domain
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR020683 Ankyrin repeat-containing domain
    Family IPR022362 Neurogenic locus Notch 1
    Domain IPR024600 Domain of unknown function DUF3454, notch
    Homologous_superfamily IPR035993 Notch-like domain superfamily
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA notch1b-202 (1)    Ensembl 7824
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM notch1b No data available
    MARKER RELATIONSHIPS
    notch1b Contained in: [BAC] DKEY-157G20 (order this), RP71-31M18 (1)
    notch1b Encodes: [EST] eu523 (1), fc55e11
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131302 (1) 7797 bp
    Genomic GenBank:BX119981 (1) 158974 bp
    Select Tool
    Polypeptide UniProtKB:A0PGH6 (1) 2465 aa
    Sequence Clusters UniGene:75825 (1)
    Sequence Information (all 24)
    ORTHOLOGY for notch1b ( Chr: 5 )
    CITATIONS (203)