Gene

notch1b

ID

ZDB-GENE-990415-183

Name

notch receptor 1b

Symbol

notch1b Nomenclature History

Previous Names

etID309871.5 (1)
wu:fc55e11

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to localize to plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Orthologous to human NOTCH1 (notch receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

174 figures from 117 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu523 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With notch1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Adams-Oliver syndrome	Alliance	Adams-Oliver syndrome 5	616028
aortic valve disease 1	Alliance	Aortic valve disease 1	109730

Associated With notch1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000800	Notch domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR010660	Notch, NOD domain
Domain	IPR011656	Notch, NODP domain
Domain	IPR024600	Notch, C-terminal
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR008297	Notch
Family	IPR022362	Neurogenic locus notch homolog protein 1
Family	IPR050906	Notch signaling pathway
Family	IPR051355	Notch and Slit guidance protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035993	Notch-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	Neurogenic locus notch homolog protein 1	Notch	NOTCH1 EGF-like calcium-binding domain	Notch and Slit guidance protein	Notch, C-terminal	Notch domain	Notch-like domain superfamily	Notch, NOD domain	Notch, NODP domain	Notch signaling pathway
UniProtKB:A0PGH6 InterPro	2465
UniProtKB:A0A8M2BFY6 InterPro	2482

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	notch1b-201 (1) Ensembl	Ensembl	7,781 nt	Select Tool ZFIN BLAST
mRNA	notch1b-202 (1) Ensembl	Ensembl	7,824 nt	Select Tool
mRNA	notch1b-203 (1) Ensembl	Ensembl	2,314 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations