ZFIN ID: ZDB-FIG-111028-26
Dalgin et al., 2011 - Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development (Cambridge, England)   138(21):4597-4608 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage: Prim-5
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Prim-5

Fig. 2 Mnx1-deficient embryos have endocrine pancreas defects. (A-F) Confocal images of the dorsal pancreatic bud at 24 hpf. ins (green) and isl1 (red) transcripts were detected by double-fluorescent in situ hybridization (FISH) in control (A-C) or Mnx1 MO1-injected (D-F) zebrafish embryos. Anterior to left. (G) Mean (± s.d.) number of cells positive for insulin (ins) or isl1 (red) in control and mnx1 morphants. *, P<0.001 (t-test, two-tailed distribution, Bonferroni correction); control, n=35; Mnx1 MO1, n=50.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
ins AB control Prim-5 posterior pancreatic bud pancreatic B cell ISH
AB + MO1-mnx1 standard conditions Prim-5 posterior pancreatic bud pancreatic B cell ISH
isl1a AB control Prim-5 posterior pancreatic bud ISH
AB + MO1-mnx1 standard conditions Prim-5 posterior pancreatic bud ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-mnx1 standard conditions Prim-5 endocrine pancreas development decreased process quality, abnormal
Prim-5 posterior pancreatic bud has fewer parts of type pancreatic B cell, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development