FIGURE

Fig. 6

ID

ZDB-FIG-110214-6

Publication

Radosevic et al., 2011 - Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear

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Fig. 6

Retinoic acid, but not Notch, regulates her9 and tbx1 expression in the inner ear. (A-F) Expression of her9 (A,C), tbx1 (B,D) and atoh1a (E,F) at 24 hpf in control (DMSO) and Notch-inhibited (DAPT-treated) zebrafish embryos. (G-R) Expression of her9 (G,K,O), tbx1 (H,L,P), neurog1 (I,M,Q) and neurod (J,N,R) at 24 hpf in embryos treated with DMSO (G-J), the retinaldehyde dehydrogenase inhibitor DEAB (K-N) or retinoic acid (RA) (O-R) from 10.5 hpf. The shift of the boundary of the neurogenic and non-neurogenic compartments is depicted by the white line in each otic vesicle. A-F and G-R are at the same magnification.

Expression Data

Genes:	atoh1a her9 neurod1 neurog1 tbx1
Fish:	AB
Conditions:	chemical treatment: DAPT chemical treatment: pharmaceutical chemical treatment: all-trans-retinoic acid
Anatomical Term:	otic vesicle
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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