Gene
neurog1
- ID
- ZDB-GENE-990415-174
- Name
- neurogenin 1
- Symbol
- neurog1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in generation of neurons; hindbrain morphogenesis; and peripheral nervous system development. Acts upstream of or within several processes, including negative regulation of neurogenesis; nervous system development; and olfactory placode development. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural rod; and neural tube. Orthologous to human NEUROG1 (neurogenin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 264 figures from 167 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb260 (37 images)
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1059Tg | Transgenic insertion | 3' UTR | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-neurog1 | N/A | (17) |
| MO2-neurog1 | N/A | (3) |
| MO3-neurog1 | N/A | (4) |
| MO4-neurog1 | N/A | (12) |
| MO5-neurog1 | N/A | (4) |
| MO6-neurog1 | N/A | (4) |
| MO8-neurog1 | N/A | (3) |
| MO9-neurog1 | N/A | Zhang et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay | 620469 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:O42606 | InterPro | 208 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neurog1-201
(1)
|
Ensembl | 1,393 nt |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-neurog1 | polyclonal | Mouse |
|
Abcam plc
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-3.1neurog1:GFP) |
|
| 1 | (32) | |
| Tg(-8.4neurog1:GFP) |
|
| 1 | (54) | |
| Tg(-8.4neurog1:nRFP) |
|
| 1 | (20) | |
| Tg2(hsp70l:neurog1) |
|
| 1 | (2) | |
| Tg(-3.1neurog1:GFP-CAAX) |
|
| 1 | (6) | |
| Tg(-3.1neurog1:GFP-rab7a) |
|
| 1 | Ponomareva et al., 2016 | |
| Tg(-3.1neurog1:GFP-rab7a_K157N) |
|
| 1 | Ponomareva et al., 2016 | |
| Tg(-3.1neurog1:GFP-rab7a_L129F) |
|
| 1 | Ponomareva et al., 2016 | |
| Tg(-3.1neurog1:TagRFP) |
|
| 1 | (2) | |
| Tg(-3.1neurog1:TagRFP-CAAX) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-171N3 | ZFIN Curated Data | |
| Encodes | EST | cb260 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:65737 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76812 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131041 (1) | 1399 nt | ||
| Genomic | GenBank:BX571940 (1) | 179550 nt | ||
| Polypeptide | UniProtKB:O42606 (1) | 208 aa |
- Brown, R.I., Barber, H.M., Kucenas, S. (2024) Satellite glial cell manipulation prior to axotomy enhances developing dorsal root ganglion central branch regrowth into the spinal cord. Glia. 72:176617841766-1784
- Ding, S., Aziz, T., Meng, A., Jia, S. (2024) Aagab is required for zebrafish larval development by regulating neural activity. Journal of genetics and genomics = Yi chuan xue bao. 51(6):630-641
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Cotellessa, L., Marelli, F., Duminuco, P., Adamo, M., Papadakis, G.E., Bartoloni, L., Sato, N., Lang-Muritano, M., Troendle, A., Dhillo, W.S., Morelli, A., Guarnieri, G., Pitteloud, N., Persani, L., Bonomi, M., Giacobini, P., Vezzoli, V. (2023) Defective Jagged1 signaling impacts GnRH development and contributes to congenital hypogonadotropic hypogonadism. JCI insight. 8(5):
- Kent, M.R., Calderon, D., Silvius, K.M., Kucinski, J.P., LaVigne, C.A., Cannon, M.V., Kendall, G.C. (2023) Zebrafish her3 knockout impacts developmental and cancer-related gene signatures. Developmental Biology. 496:1141-14
- Leid, J., Gray, R., Rakita, P., Koenig, A.L., Tripathy, R., Fitzpatrick, J.A.J., Kaufman, C., Solnica-Krezel, L., Lavine, K.J. (2023) Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism. Biology Open. 12(7):
- Leino, S.A., Constable, S.C.J., Streit, A., Wilkinson, D.G. (2023) Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. Development (Cambridge, England). 150(18):
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