Gene

neurog1

ID
ZDB-GENE-990415-174
Name
neurogenin 1
Symbol
neurog1 Nomenclature History
Previous Names
  • neurod3
  • neurogenin1
  • neurogenin (1)
  • ngr1
  • cb260 (1)
  • chunp6899
  • neurogenic differentiation 3 (1)
  • ngn1
  • Zath4c (1)
  • zNgn1
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and chromatin binding activity. Involved in generation of neurons; hindbrain morphogenesis; and peripheral nervous system development. Acts upstream of or within several processes, including negative regulation of neurogenesis; nervous system development; and olfactory placode development. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural rod; and neural tube. Orthologous to human NEUROG1 (neurogenin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
264 figures from 167 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
26 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With neurog1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay 620469
1 - 1 of 1
Associated With neurog1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR050359 Basic helix-loop-helix transcription factors
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Basic helix-loop-helix transcription factors Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:O42606 InterPro 208
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA neurog1-201 (1) Ensembl 1,393 nt
1 - 1 of 1
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-neurog1 polyclonal Mouse
  • IHC
Abcam plc
1
1 - 1 of 1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations