Fig. 3
- ID
- ZDB-FIG-110214-3
- Publication
- Radosevic et al., 2011 - Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear
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Depletion of her9 distorts the development of the SAG but not the generation of hair cells. (A,B) Three-dimensional reconstruction of the SAG at 48 hpf visualized in wild-type and her9-MO-injected zebrafish embryos carrying the islet3:GFP transgene. Arrowheads point to SAG branches. (C,D) Expression of atoh1a in wild-type and Her9 morphant embryos at 24 hpf. (E,F) Sagittal sections of posterior macula showing GFP fluorescence under the control of brn3c (pou4f3) reporter in a wild-type and her9-MO-injected embryo. (G,H) Three-dimensional reconstruction of selected confocal sections showing the otic cristae in wild-type and her9-MO-injected embryos. GFP in adjacent neuromasts of the lateral line has been removed for clarity. C,D, E,F and G,H are at the same magnification. SAG, statoacoustic ganglion; am, anterior macula; ac, anterior crista; lc, lateral crista; pc, posterior crista. |
| Genes: | |
|---|---|
| Fish: | (all 6) |
| Knockdown Reagent: | |
| Anatomical Terms: | (all 6) |
| Stage Range: | Prim-5 to Day 4 |