Gene
neurod1
- ID
- ZDB-GENE-990415-172
- Name
- neuronal differentiation 1
- Symbol
- neurod1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within several processes, including endocrine pancreas development; negative regulation of Notch signaling pathway; and neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including endoderm; nervous system; neural plate; neurogenic placode; and pancreatic system. Human ortholog(s) of this gene implicated in glucose intolerance; hyperglycemia; maturity-onset diabetes of the young type 6; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human NEUROD1 (neuronal differentiation 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 225 figures from 144 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-neurod1 | (2) | |
| CRISPR2-neurod1 | (2) | |
| CRISPR3-neurod1 | Reuter et al., 2022 | |
| CRISPR4-neurod1 | Reuter et al., 2022 | |
| CRISPR5-neurod1 | Reuter et al., 2022 | |
| MO1-neurod1 | N/A | (7) |
| MO2-neurod1 | N/A | (2) |
| MO3-neurod1 | N/A | Flasse et al., 2013 |
1 - 8 of 8
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| maturity-onset diabetes of the young type 6 | Alliance | Maturity-onset diabetes of the young 6 | 606394 |
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR022575 | Neurogenic differentiation factor, domain of unknown function |
| Family | IPR016637 | Neurogenic differentiation factor NeuroD |
| Family | IPR050359 | Basic helix-loop-helix transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
1 - 5 of 5
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Neurogenic differentiation factor, domain of unknown function | Neurogenic differentiation factor NeuroD |
|---|---|---|---|---|---|---|---|
| UniProtKB:O42202 | InterPro | 350 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
neurod1-201
(1)
|
Ensembl | 2,422 nt |
1 - 1 of 1
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-neurod | monoclonal | Mouse |
|
11 | |||
| Ab3-neurod1 |
|
2 |
1 - 2 of 2
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(neurod1:EGFP) |
|
| 1 | (125) | |
| Tg(-2.5neurod1:EGFP) |
|
| 1 | (11) | |
| Tg(-5.0neurod1:Cre,-0.8-myl7:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(-5.0neurod1:CreERT2,-0.8myl7:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
| Tg(-5kbneurod1:GGECO) |
|
| 1 | (3) | |
| Tg(-5kbneurod1:Hsa.PGC1A-2A-mRFP) |
|
| 1 | (2) | |
| Tg(-5kbneurod1:MITO-mEos) |
|
| 1 | (2) | |
| Tg(-5kbneurod1:MITO-RGECO) |
|
| 1 | (3) | |
| Tg(-5kb-neurod1:Rno.Tomm20-HaloTag-Hsa.SEC61B) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(-5kbneurod1:vapb-HaloTag) |
|
| 1 | Zebrafish Nomenclature Committee |
1 - 10 of 34
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-165L22 | ZFIN Curated Data | |
| Encodes | EST | cegs2212 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:65901 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77342 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130978 (1) | 2250 nt | ||
| Genomic | GenBank:CR753862 (1) | 201337 nt | ||
| Polypeptide | UniProtKB:O42202 (1) | 350 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Jiang, X., Ly, O.T., Chen, H., Zhang, Z., Ibarra, B.A., Pavel, M.A., Brown, G.E., Sridhar, A., Tofovic, D., Swick, A., Marszalek, R., Vanoye, C.G., Navales, F., George, A.L., Khetani, S.R., Rehman, J., Gao, Y., Darbar, D., Saxena, A. (2024) Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility. iScience. 27:110395110395
- Lu, X., Song, Y., Wang, J., Cai, Y., Peng, S., Lin, J., Lai, B., Sun, J., Liu, T., Chen, G., Xing, L. (2024) Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes. The American journal of pathology. 194(6):1062-1077
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Azbazdar, Y., Poyraz, Y.K., Ozalp, O., Nazli, D., Ipekgil, D., Cucun, G., Ozhan, G. (2023) High-fat diet feeding triggers a regenerative response in the adult zebrafish brain. Molecular neurobiology. 60(5):2486-2506
- Barazzuol, L., Cieri, D., Facchinello, N., Calì, T., Washbourne, P., Argenton, F., Pizzo, P. (2023) Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis. Cells. 12(3):
- Huang, S., Zhang, H., Chen, W., Su, N., Yuan, C., Zhang, J., Xiang, S., Hu, X. (2023) CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Genes. 14(5):
1 - 10 of 283
Show