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Fig. 6

ID

ZDB-FIG-100420-6

Publication

Huang et al., 2010 - Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish

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Fig. 6

Fig. 6. Knockdown of smarcal1 changes the expressions of cell cycle-related genes. Real-time PCR experiments show that mRNA levels of cyclinA (A) was suppressed and p21 (B) was increased by smarcal1 MO at 1 dpf and 2 dpf. The levels of cyclinB1, cyclinD1, cyclinE were not changed at 1 dpf, whereas the expressions of cyclinD1 increased at 2 dpf (A). The expression levels of cdkn1b (p27) and cdkn1c (p57) remained no significant change (B). The results were obtained from at least three experiments. β-actin mRNA was measured as an internal control. Data are presented as means � SE. low asteriskP < 0.05; low asterisklow asteriskP < 0.01.

Expression Data

Genes:	ccna2 ccnb1 ccnd1 ccne1 cdkn1a cdkn1bb cdkn1ca
Fish:	AB AB + MO1-smarcal1
Knockdown Reagent:	MO1-smarcal1
Anatomical Term:	whole organism
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 339(1), Huang, C., Gu, S., Yu, P., Yu, F., Feng, C., Gao, N., and Du, J., Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish, 89-100, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.