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ZIRC
ZFIN ID: ZDB-GENE-040123-1
Gene Name: cyclin-dependent kinase inhibitor 1Ca
Gene Symbol: cdkn1ca    Nomenclature History

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Previous Names: cb961 (1), cdkn1c, p21-like (1), p27Xic1-a (1), p57kip2 (1), zgc:86618

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have cyclin-dependent protein serine/threonine kinase inhibitor activity and kinase activity. Involved in cell fate specification; glial cell differentiation; and negative regulation of mitotic cell cycle. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Is expressed in several structures, including mesoderm; muscle; nervous system; neural tube; and notochord. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C).
Genome Resources: Alliance (1),  Gene:399483 (1),  Ensembl(GRCz11):ENSDARG00000010878 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38636 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdkn1ca N/A 2
    MO2-cdkn1ca N/A 3
    MO3-cdkn1ca N/A 1
    DISEASE ASSOCIATED WITH cdkn1ca HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Beckwith-Wiedemann syndrome Alliance Beckwith-Wiedemann syndrome 130650
    IMAGe syndrome Alliance IMAGE syndrome 614732
    DISEASE ASSOCIATED WITH cdkn1ca VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell fate specification (more)
    Cellular Component nucleus (more)
    Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003175 (1)
  • InterPro:IPR029842 (1)
  • Pfam:PF02234 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdkn1ca-201 (1)    Ensembl 1566
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdkn1ca
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:cdkn1c-MYC) hsp70l cdkn1ca Danio rerio 1 3
    MARKER RELATIONSHIPS
    cdkn1ca Contained in: [BAC] DKEY-7P8 (1) (order this)
    cdkn1ca Encodes: [EST] cb961 (1) (order this)
    [cDNA] MGC:86618 (1) (order this), MGC:173881 (1) (order this)
    cdkn1ca Is Hybridized by: [STS] chunp487
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002040 (1) 1199 bp
    Genomic GenBank:AL928843 (1) 179577 bp
    Select Tool
    Polypeptide UniProtKB:Q6IQT7 (1) 212 aa
    Sequence Clusters UniGene:76099 (1)
    Sequence Information (all 15)
    ORTHOLOGY for cdkn1ca ( Chr: 7 )
    CITATIONS (70)