Gene

cdkn1bb

ID

ZDB-GENE-030521-13

Name

cyclin-dependent kinase inhibitor 1Bb

Symbol

cdkn1bb Nomenclature History

Previous Names

cdkn1b (1)
kip1
fb64g10
im:7152670
p27
sb:cb611
wu:fb63g10
wu:fb64g10 (1)
wu:fe18e03

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein-folding chaperone binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of cell population proliferation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within phosphorylation; regulation of cell cycle; and regulation of cell population proliferation. Predicted to be located in endosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; nervous system; pectoral fin; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

33 figures from 22 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb611 (12 images)
IMAGE:7152670 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdkn1bb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
multiple endocrine neoplasia type 4	Alliance	Multiple endocrine neoplasia, type IV	610755

Associated With cdkn1bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003175	Cyclin-dependent kinase inhibitor domain
Family	IPR029843	Cyclin-dependent kinase inhibitor 1B
Homologous_superfamily	IPR044898	Cyclin-dependent kinase inhibitor domain superfamily

Domain Details Per Protein

Protein	Length	Cyclin-dependent kinase inhibitor 1B	Cyclin-dependent kinase inhibitor domain	Cyclin-dependent kinase inhibitor domain superfamily
UniProtKB:Q90YX4 InterPro	179

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	cdkn1bb-201 (1) Ensembl	1921 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cdkn1bb-002 (1) Ensembl	864 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations