Gene
cdkn1bb
- ID
- ZDB-GENE-030521-13
- Name
- cyclin dependent kinase inhibitor 1Bb
- Symbol
- cdkn1bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein-folding chaperone binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of epithelial cell proliferation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in endosome. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; nervous system; pectoral fin; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb611 (12 images)
- IMAGE:7152670 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| multiple endocrine neoplasia type 4 | Alliance | Multiple endocrine neoplasia, type IV | 610755 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin-dependent kinase inhibitor domain | Cyclin-dependent kinase inhibitor domain superfamily |
|---|---|---|---|
|
UniProtKB:Q90YX4
|
179 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdkn1bb-201
(1)
|
Ensembl | 1,921 nt | ||
| ncRNA |
cdkn1bb-002
(1)
|
Ensembl | 864 nt |
Interactions and Pathways
No data available
Plasmids
No data available