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ZIRC
ZFIN ID: ZDB-GENE-030521-13
Gene Name: cyclin-dependent kinase inhibitor 1Bb
Gene Symbol: cdkn1bb    Nomenclature History

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Previous Names: cdkn1b (1), kip1, fb64g10, im:7152670, p27, sb:cb611, wu:fb63g10, wu:fb64g10 (1), wu:fe18e03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have chaperone binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Predicted to be involved in G1/S transition of mitotic cell cycle; negative regulation of cell cycle; and negative regulation of cell population proliferation. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Is expressed in several structures, including axis; nervous system; pectoral fin; polster; and solid lens vesicle. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).
Genome Resources: Alliance (1),  Gene:368329 (1),  Ensembl(GRCz11):ENSDARG00000054271 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-cdkn1bb N/A 3
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cdkn1bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple endocrine neoplasia type 4 Alliance Multiple endocrine neoplasia, type IV 610755
DISEASE ASSOCIATED WITH cdkn1bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell cycle arrest (more)
Cellular Component cytoplasm (more)
Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003175 (1)
  • InterPro:IPR029843 (1)
  • Pfam:PF02234 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdkn1bb-201 (1)    Ensembl 1921
    ncRNA cdkn1bb-002 (1) 864
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdkn1bb No data available
    MARKER RELATIONSHIPS
    cdkn1bb Contained in: [BAC] CH211-218P2 (1) (order this)
    cdkn1bb Encodes: [EST] cb611 (1) (order this), fb63g10 (1), fb64g10, fe18e03 (1), IMAGE:7152670 (1) (order this)
    [cDNA] MGC:65754 (1) (order this), MGC:77582 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212792 (1) 1880 bp
    Genomic GenBank:CR354430 (1) 197231 bp
    Select Tool
    Polypeptide UniProtKB:Q90YX4 (1) 179 aa
    Sequence Clusters UniGene:75267 (1)
    Sequence Information (all 24)
    ORTHOLOGY for cdkn1bb ( Chr: 25 )
    CITATIONS (76)