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ZIRC
ZFIN ID: ZDB-GENE-980526-176
Gene Name: cyclin D1
Gene Symbol: ccnd1    Nomenclature History

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Previous Names: cycd1 (1), cb161 (1), etID37810.7 (1), fb52e01, fc45c08, fc83a12, id:ibd1198, wu:fb52e01 (1), wu:fc45c08, wu:fc83a12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to contribute to protein kinase activity. Involved in camera-type eye morphogenesis; neuron cellular homeostasis; and regulation of neural retina development. Predicted to localize to several cellular components, including the cyclin-dependent protein kinase holoenzyme complex; nucleus; and transcriptional repressor complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); invasive lobular carcinoma; pancreatic cancer (multiple); and von Hippel-Lindau disease. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and neural tube. Orthologous to human CCND1 (cyclin D1).
Genome Resources: Alliance (1),  Gene:30222 (1),  Ensembl(GRCz11):ENSDARG00000101637 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016165Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la016166Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026147Tg Transgenic Insertion Unknown Unknown DNA
    sa14707 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21083 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34190 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ccnd1 N/A 2
    DISEASE ASSOCIATED WITH ccnd1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance {Colorectal cancer, susceptibility to} 114500
    multiple myeloma Alliance {Multiple myeloma, susceptibility to} 254500
    von Hippel-Lindau disease Alliance {von Hippel-Lindau syndrome, modifier of} 193300
    DISEASE ASSOCIATED WITH ccnd1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of neural retina development (more)
    Cellular Component nucleus (more)
    Molecular Function transcription corepressor activity (more)
    GO Terms (all 21)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript ccnd1-201 (1)    Ensembl 881
    mRNA ccnd1-203 (1)    Ensembl 2742
    ccnd1-204 (1)    Ensembl 840
    ncRNA ccnd1-004 (1)    Ensembl 673
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ccnd1 polyclonal Rabbit WB Millipore
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ccnd1 No data available
    MARKER RELATIONSHIPS
    ccnd1 Contained in: [BAC] CH211-188I17 (1) (order this)
    ccnd1 Contains: [SNP] rs3728104 (1)
    ccnd1 Encodes: [EST] cb161 (1) (order this), fb52e01 (1), fc45c08, fc83a12 (1) (order this), ibd1198 (order this)
    [cDNA] MGC:86577 (1) (order this), MGC:173833 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131025 (1) 2479 bp
    Genomic GenBank:AL929586 (1) 154808 bp
    Select Tool
    Polypeptide UniProtKB:A7YYE4 (1) 291 aa
    Sequence Clusters UniGene:75056 (1)
    Sequence Information (all 36)
    ORTHOLOGY for ccnd1 ( Chr: 7 )
    CITATIONS (194)