Gene
ccnd1
- ID
- ZDB-GENE-980526-176
- Name
- cyclin D1
- Symbol
- ccnd1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to contribute to protein kinase activity. Involved in camera-type eye morphogenesis; neuron cellular homeostasis; and regulation of neural retina development. Predicted to localize to several cellular components, including cyclin-dependent protein kinase holoenzyme complex; nucleus; and transcriptional repressor complex. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); invasive lobular carcinoma; malignant glioma; and von Hippel-Lindau disease. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and neural tube. Orthologous to human CCND1 (cyclin D1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 129 figures from 96 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb161 (32 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Duffy et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | {Colorectal cancer, susceptibility to} | 114500 |
| multiple myeloma | Alliance | {Multiple myeloma, susceptibility to} | 254500 |
| von Hippel-Lindau disease | Alliance | {von Hippel-Lindau syndrome, modifier of} | 193300 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cyclin | Cyclin, C-terminal domain | Cyclin-like domain | Cyclin-like superfamily | Cyclin, N-terminal | Cyclins, cyclin-box |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90459
|
291 | ||||||
|
UniProtKB:A7YYE4
|
291 |
Interactions and Pathways
No data available
Plasmids
No data available