Gene

ccnd1

ID
ZDB-GENE-980526-176
Name
cyclin D1
Symbol
ccnd1 Nomenclature History
Previous Names
  • cycd1 (1)
  • cb161 (1)
  • etID37810.7 (1)
  • fb52e01
  • fc45c08
  • fc83a12
  • id:ibd1198
  • wu:fb52e01 (1)
  • wu:fc45c08
  • wu:fc83a12 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity and transcription corepressor activity. Involved in camera-type eye morphogenesis; neuron cellular homeostasis; and regulation of neural retina development. Predicted to localize to several cellular components, including cyclin-dependent protein kinase holoenzyme complex; nucleus; and transcription repressor complex. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and neural tube. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); invasive lobular carcinoma; malignant glioma; and von Hippel-Lindau disease. Orthologous to human CCND1 (cyclin D1).
Genome Resources
Note
None
Expression
All Expression Data
100 figures from 70 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Duffy et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ccnd1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance {Colorectal cancer, susceptibility to} 114500
multiple myeloma Alliance {Multiple myeloma, susceptibility to} 254500
von Hippel-Lindau disease Alliance {von Hippel-Lindau syndrome, modifier of} 193300
Associated With ccnd1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004367 Cyclin, C-terminal domain
Domain IPR006671 Cyclin, N-terminal
Domain IPR013763 Cyclin-like
Family IPR015451 Cyclin D
Family IPR039361 Cyclin
Homologous_superfamily IPR036915 Cyclin-like superfamily
Domain Details Per Protein
Protein Length Cyclin Cyclin, C-terminal domain Cyclin D Cyclin-like Cyclin-like superfamily Cyclin, N-terminal
UniProtKB:Q90459 291
UniProtKB:A0A0R4IEY8 210
UniProtKB:Q8QFP4 291
UniProtKB:A7YYE4 291
UniProtKB:A0A0R4IAQ3 76
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ccnd1 polyclonal Rabbit
  • WB
Millipore
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations