ZFIN Gene: ccnb1

ZFIN ID: ZDB-GENE-000406-10

ZFIN ID: ZDB-GENE-000406-10

Gene Name:

cyclin B1

Gene Symbol:

ccnb1 Nomenclature History

Previous Names:

ccnb (1), cycb1, cycb, cb267 (1), cyclinB (1), etID61116.5 (1), wu:fa19g04, wu:fb16d01, wu:fb16e07 (1), wu:fi21c01 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 5 Mapping Details/Browsers

Description:

Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity. Involved in oocyte maturation. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including nervous system; oocyte; pectoral fin; trunk mesenchyme; and unfertilized egg. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1).

Genome Resources:

Alliance (1), Gene:58025 (1), Ensembl(GRCz11):ENSDARG00000051923 (2)

GENE EXPRESSION
All Expression Data:	46 figures from 25 publications
Directly Submitted Expression Data:	12 figures (13 images) from Rauch et al., 2003 [fb16e07]
	6 figures (15 images) from Thisse et al., 2001 [cb267]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	brain central nervous system ectoderm eye head hindbrain immature eye lateral mesenchyme derived from mesoderm midbrain nervous system neural keel neural plate oocyte pole plasm oocyte oocyte stage I cytoplasm oocyte stage I pole plasm oocyte stage I oocyte stage II anterior region oocyte stage II cytoplasm oocyte stage II pole plasm oocyte stage III anterior region oocyte stage III cell cortex region oocyte stage III pole plasm oocyte stage III oocyte stage IV cell cortex region oocyte stage IV pole plasm oocyte stage V pole plasm oocyte stage V optic tectum otic vesicle paraxial mesoderm pectoral fin pectoral fin musculature pharyngeal arch 3-7 skeleton proliferative region retina spinal cord tail bud unfertilized egg pole plasm unspecified whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hi2734Tg	Transgenic Insertion	Intron 1	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa33717	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38506	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40559	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44618	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
zf3075	Indel	Unknown	Unknown	CRISPR

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-ccnb1	zf3075	1
MO1-ccnb1	N/A	1

PHENOTYPE

Data:	2 figures from 2 publications
Observed in:	central nervous system head nervous system whole organism

DISEASE ASSOCIATED WITH ccnb1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH ccnb1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	oocyte maturation (more)
Cellular Component	host cell nucleus (more)
Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity (more)

GO Terms (all 12)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	ccnb1-201 (1)	1901	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ccnb1-202 (1)	559	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ccnb1-204 (1)	658	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	ccnb1-205 (1)	770	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ccnb1-005 (1)	876	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM ccnb1

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(ccnb1:EGFP)	ccnb1	EGFP	Danio rerio	1	3
tg(krt18a.1:ccnb1-gfp)	krt18a.1	ccnb1, GFP	Danio rerio	1	1
Tg(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP	Danio rerio, Xenopus laevis	1	3
Tg1(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP, TC	Danio rerio, Xenopus laevis	1	2
Tg1(Xla.Eef1a1-UTR-ccnb1:TC-EGFP)	ccnb1	EGFP	Danio rerio, Xenopus laevis	1	2
Tg2(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP, TC	Danio rerio, Xenopus laevis	1	2
Tg2(Xla.Eef1a1-UTR-ccnb1:TC-EGFP)	ccnb1	EGFP	Danio rerio, Xenopus laevis	1	2
Tg3(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP, TC	Danio rerio, Xenopus laevis	1	2
Tg3(Xla.Eef1a1-UTR-ccnb1:TC-EGFP)		ccnb1, EGFP	Danio rerio, Xenopus laevis	1	2
Tg4(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP, TC	Danio rerio, Xenopus laevis	1	2
Tg5(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP, TC	Danio rerio, Xenopus laevis	1	2
Tg6(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1)	ccnb1	ccnb1, EGFP, TC	Danio rerio, Xenopus laevis	1	2

MARKER RELATIONSHIPS

ccnb1 Contained in:	[BAC] DKEY-267K7 (1) (order this)
ccnb1 Contains:	[SNP] rs3727902 (1), rs3727903 (1)
ccnb1 Encodes:	[EST] cb267 (1) (order this), fa19g04, fb16d01, fb16e07 (1) (order this), fi21c01 (1) [cDNA] MGC:55916 (1), MGC:66218 (1), MGC:77100 (1), MGC:174512 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131513 (1)	1519 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX571667 (1)	151582 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q9IB44 (1)	398 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 40)

ORTHOLOGY for ccnb1 ( Chr: 5 )

CITATIONS (113)

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