Gene

ccnb1

ID

ZDB-GENE-000406-10

Name

cyclin B1

Symbol

ccnb1 Nomenclature History

Previous Names

ccnb (1)
cycb1
cycb
cb267 (1)
cyclinB (1)
etID61116.5 (1)
spct
spr(l)
wu:fa19g04
wu:fb16d01
wu:fb16e07 (1)
wu:fi21c01 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within oocyte maturation. Predicted to be located in cytosol. Predicted to be part of cyclin B1-CDK1 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including gonad; nervous system; pectoral fin; trunk mesenchyme; and unfertilized egg. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

63 figures from 37 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb267 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ccnb1 Human Ortholog

No data available

Associated With ccnb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR048258	Cyclins, cyclin-box
Domain	IPR004367	Cyclin, C-terminal domain
Domain	IPR006671	Cyclin, N-terminal
Domain	IPR013763	Cyclin-like domain
Domain	IPR048026	G2/mitotic-specific cyclin-B1, first cyclin box
Family	IPR039361	Cyclin
Family	IPR046965	Cyclin A/B-like
Homologous_superfamily	IPR036915	Cyclin-like superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Cyclin	Cyclin A/B-like	Cyclin, C-terminal domain	Cyclin-like domain	Cyclin-like superfamily	Cyclin, N-terminal	Cyclins, cyclin-box	G2/mitotic-specific cyclin-B1, first cyclin box
UniProtKB:Q9IB44	InterPro	398

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ccnb1-201 (1) Ensembl	Ensembl	1,901 nt	Select Tool ZFIN BLAST
mRNA	ccnb1-202 (1) Ensembl	Ensembl	559 nt	Select Tool ZFIN BLAST
mRNA	ccnb1-204 (1) Ensembl	Ensembl	658 nt	Select Tool ZFIN BLAST
mRNA	ccnb1-205 (1) Ensembl	Ensembl	770 nt	Select Tool ZFIN BLAST
ncRNA	ccnb1-005 (1) Ensembl	Ensembl	876 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations