ZFIN ID: ZDB-GENE-000406-10
Gene Name: cyclin B1
Gene Symbol: ccnb1    Nomenclature History

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Previous Names: ccnb (1), cycb1, cycb, cb267 (1), cyclinB (1), etID61116.5 (1), wu:fa19g04, wu:fb16d01, wu:fb16e07 (1), wu:fi21c01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have cyclin-dependent protein serine/threonine kinase regulator activity. Involved in oocyte maturation. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including nervous system; oocyte; pectoral fin; trunk mesenchyme; and unfertilized egg. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1).
Genome Resources: Alliance (1),  Gene:58025 (1),  Ensembl(GRCz11):ENSDARG00000051923 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2734Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33717 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38506 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40559 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44618 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zf3075 Indel Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ccnb1 1
    MO1-ccnb1 N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH ccnb1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ccnb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oocyte maturation (more)
    Cellular Component host cell nucleus (more)
    Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ccnb1-201 (1)    Ensembl 1901
    ccnb1-202 (1)    Ensembl 559
    ccnb1-204 (1)    Ensembl 658
    ccnb1-205 (1)    Ensembl 770
    ncRNA ccnb1-005 (1)    Ensembl 876
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ccnb1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(ccnb1:EGFP) ccnb1 EGFP Danio rerio 1 3
    tg(krt18a.1:ccnb1-gfp) krt18a.1 ccnb1GFP Danio rerio 1 1
    Tg(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFP Danio rerioXenopus laevis 1 3
    Tg1(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFPTC Danio rerioXenopus laevis 1 2
    Tg1(Xla.Eef1a1-UTR-ccnb1:TC-EGFP) ccnb1 EGFP Danio rerioXenopus laevis 1 2
    Tg2(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFPTC Danio rerioXenopus laevis 1 2
    Tg2(Xla.Eef1a1-UTR-ccnb1:TC-EGFP) ccnb1 EGFP Danio rerioXenopus laevis 1 2
    Tg3(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFPTC Danio rerioXenopus laevis 1 2
    Tg3(Xla.Eef1a1-UTR-ccnb1:TC-EGFP) ccnb1EGFP Danio rerioXenopus laevis 1 2
    Tg4(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFPTC Danio rerioXenopus laevis 1 2
    Tg5(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFPTC Danio rerioXenopus laevis 1 2
    Tg6(Xla.Eef1a1-ccnb1:TC-EGFP-STOP-ccnb1) ccnb1 ccnb1EGFPTC Danio rerioXenopus laevis 1 2
    MARKER RELATIONSHIPS
    ccnb1 Contained in: [BAC] DKEY-267K7 (1) (order this)
    ccnb1 Contains: [SNP] rs3727902 (1), rs3727903 (1)
    ccnb1 Encodes: [EST] cb267 (1) (order this), fa19g04, fb16d01, fb16e07 (1) (order this), fi21c01 (1)
    [cDNA] MGC:55916 (1), MGC:66218 (1), MGC:77100 (1), MGC:174512 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131513 (1) 1519 nt
    Genomic GenBank:BX571667 (1) 151582 nt
    Select Tool
    Polypeptide UniProtKB:Q9IB44 (1) 398 aa
    Sequence Information (all 40)
    ORTHOLOGY for ccnb1 ( Chr: 5 )
    CITATIONS (113)