Gene

cdkn1a

ID
ZDB-GENE-070705-7
Name
cyclin-dependent kinase inhibitor 1A
Symbol
cdkn1a Nomenclature History
Previous Names
  • cip1
  • p21
  • waf1
  • si:ch1073-48m5.2
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable protein kinase inhibitor activity. Acts upstream of or within aorta development; response to X-ray; and skeletal muscle cell differentiation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hatching gland; male organism; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in high grade glioma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
96 figures from 86 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdkn1a Human Ortholog
No data available
Associated With cdkn1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003175 Cyclin-dependent kinase inhibitor domain
Family IPR029841 Cyclin-dependent kinase inhibitor 1
Homologous_superfamily IPR044898 Cyclin-dependent kinase inhibitor domain superfamily
Domain Details Per Protein
Protein Length Cyclin-dependent kinase inhibitor 1 Cyclin-dependent kinase inhibitor domain Cyclin-dependent kinase inhibitor domain superfamily
UniProtKB:A5WWG2 154
UniProtKB:A5WWG3 173
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-cdkn1a polyclonal Rabbit
  • WB
Cosmo Bio Co. LTD.
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations