Gene
myca
- ID
- ZDB-GENE-990415-162
- Name
- MYC proto-oncogene, bHLH transcription factor a
- Symbol
- myca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hematopoietic stem cell differentiation; regulation of vasculature development; and vasculature development. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pronephros. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 75 figures from 58 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64149 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shi et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myca | Yakulov et al., 2018 | |
| MO1-myca | N/A | (2) |
| MO2-myca | N/A | (2) |
| MO3-myca | N/A | Mitra et al., 2019 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Burkitt lymphoma | Alliance | Burkitt lymphoma, somatic | 113970 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003327 | Leucine zipper, Myc |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR012682 | Transcription regulator Myc, N-terminal |
| Family | IPR002418 | Transcription regulator Myc |
| Family | IPR050433 | Myc family transcription factors |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Leucine zipper, Myc | Myc family transcription factors | Myc-type, basic helix-loop-helix (bHLH) domain | Transcription regulator Myc | Transcription regulator Myc, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:P52160 | InterPro | 419 |
Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(crybb1:mCherry,LEXOP:EGFP-myca) |
| 1 | (2) | ||
| Tg(hsp70l:VP16-myca,cryaa:ECFP) |
| 1 | Ko et al., 2016 | ||
| Tg(UAS:LOXP-LOX2272-Cre-LOXP-kras_G12V-2A-PhiYFP-LOX2272-myca-2A-mKate2-LOXN-CFP) |
| 1 | Fei et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-69L10 | ZFIN Curated Data | |
| Encodes | EST | fc77a09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64149 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131412 (1) | 1869 nt | ||
| Genomic | GenBank:CT573344 (2) | 106999 nt | ||
| Polypeptide | UniProtKB:P52160 (1) | 419 aa |
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Amin, A., Morello, M., Petrara, M.R., Rizzo, B., Argenton, F., De Rossi, A., Giunco, S. (2023) Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach. Cancers. 15(10):
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Liang, F., Lu, X., Wu, B., Yang, Y., Qin, W. (2023) Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Biology. 12(4):
- Palsamy, K., Chen, J.Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., Powell, C., Goldman, D., Parent, J.M. (2023) Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 71(11):2642-2663
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
- Tang, Z., Wang, K., Lo, L., Chen, J. (2023) Tg(Δ113p53:cmyc) Transgene Upregulates glut1 Expression to Promote Zebrafish Heart Regeneration. Journal of cardiovascular development and disease. 10(6):
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Zhang, Z., Yang, C., Wang, Z., Guo, L., Xu, Y., Gao, C., Sun, Y., Zhang, Z., Peng, J., Hu, M., Jan Lo, L., Ma, Z., Chen, J. (2023) Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis. Cell death discovery. 9:227227
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
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