ZFIN ID: ZDB-GENE-040808-67
Gene Name: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Symbol: kras    Nomenclature History

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Previous Names: fa04e08, fc14b12, fc23g10, fj89d12, wu:fa04e08, wu:fc14b12, wu:fc23g10, wu:fj89d12, xRAS2 (1), zgc:85725

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Involved in embryonic cranial skeleton morphogenesis; heart development; and hemopoiesis. Predicted to localize to plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase).
Genome Resources: Alliance (1),  Gene:445289 (1),  Ensembl(GRCz11):ENSDARG00000010844 (2)
GENE EXPRESSION
All Expression Data: 2 figures from Liu et al., 2008
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb384 Indel Exon 3 Unknown CRISPR
ihb385 Indel Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-kras
1
CRISPR2-kras 1
MO1-kras N/A 1
MO2-kras N/A 1
MO3-kras N/A 1
DISEASE ASSOCIATED WITH kras HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
arteriovenous malformations of the brain Alliance Arteriovenous malformation of the brain, somatic 108010
autoimmune lymphoproliferative syndrome type 4 Alliance RAS-associated autoimmune leukoproliferative disorder 614470
breast cancer Alliance Breast cancer, somatic 114480
cardiofaciocutaneous syndrome 2 Alliance Cardiofaciocutaneous syndrome 2 615278
linear nevus sebaceous syndrome Alliance Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
lung cancer Alliance Lung cancer, somatic 211980
Noonan syndrome 3 Alliance Noonan syndrome 3 609942
oculoectodermal syndrome Alliance Oculoectodermal syndrome, somatic 600268
pancreatic carcinoma Alliance Pancreatic carcinoma, somatic 260350
stomach cancer Alliance Gastric cancer, somatic 137215
urinary bladder cancer Alliance Bladder cancer, somatic 109800
DISEASE ASSOCIATED WITH kras VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic cranial skeleton morphogenesis (more)
Cellular Component membrane (more)
Molecular Function GTPase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kras
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
tg(5xuas:egfp-2a-kras_g12d) UAS 2AEGFPkras Danio rerio 1 1
Tg(crybb1:mCherry,LEXOP:EGFP-kras_G12V) crybb1 EGFPkrasmCherry Danio rerio 1 6
tg(fabp2:lexpr,lexop:egfp-krasg12v) fabp2LEXOP EGFPkrasLEXPR Danio rerio 1 2
Tg(fabp10a:EGFP-kras_G12V) fabp10a EGFPkras Danio rerio 1 4
Tg(fabp10a:LOXP-mCherry-LOXP-EGFP-kras_G12V) fabp10a EGFPkrasLOXPmCherry Danio rerio 1 1
Tg(krt8:LEXPR,LEXOP:EGFP-kras_G12V) krt8 EGFPkras Danio rerio 1 2
Tg(nes:LOX2272-mCherry-LOX2272-EGFP-kras_G12V) nes EGFPkrasLOX2272mCherry Danio rerio 1 3
Tg(TETRE:EGFP-kras_G12V) TETRE EGFPkras Danio rerio 1 24
Tg(UAS:Dendra-kras) Dendrakras Danio rerio 1 10
tg(uas:loxp-lox2272-cre-loxp-kras_g12v-2a-phiyfp-lox2272-myca-2a-mkate2-loxn-cfp) UAS 2ACFPCrekrasLOX2272LOXNLOXPmKate2mycaPhiYFP Danio rerio 1 1
Tg(ubb:LOXP-BFP-LOXP-kras_G12V) ubb BFPkrasLOXP Danio rerio 1 1
MARKER RELATIONSHIPS
kras Encodes: [EST] fa04e08, fc14b12, fc23g10, fj89d12
[cDNA] MGC:85725 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001003744 (1) 6959 nt
Genomic GenBank:FO904995 (1) 32594 nt
Select Tool
Polypeptide UniProtKB:A0A2R8Q8S1 (1) 189 aa
Sequence Information (all 25)
ORTHOLOGY for kras ( Chr: 25 )
CITATIONS (77)