UniProt ID: P52160 |
FUNCTION: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. {ECO:0000250|UniProtKB:P01106}. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with max (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: High levels are seen in the kidney, gills and uterus. {ECO:0000269|PubMed:8474440}. DEVELOPMENTAL STAGE: Found in low abundance in the two-cell through early somite stages (<1.5 through 12 hours) and increases during later stages of growth and organ development. {ECO:0000269|PubMed:8474440}. DOMAIN: The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. {ECO:0000250|UniProtKB:P01106}. MISCELLANEOUS: Alternative translation initiation from an upstream, in- frame non-ATG (CTG) codon or a downstream ATG start site results in the production of 2 isoforms with distinct N-termini, shown in this entry as isoform 2 and isoform 1, respectively. {ECO:0000305|PubMed:3277717}. MISCELLANEOUS: [Isoform 2]: Produced by alternative translation initiation from a CTG codon, which is translated as Met. {ECO:0000305|PubMed:3277717}. |
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