ZFIN ID: ZDB-PERS-960805-643
Johnson, Stephen L.
Email: sjohnson@genetics.wustl.edu
URL: http://dbbs.wustl.edu/dbbs/website.nsf/RIB/E5C252075C20EA0486256D4E005B2D3C
Affiliation: Stephen L. Johnson Lab
Address: Department of Genetics Washington University Medical School 4566 Scott Avenue St. Louis, MO 63110 USA
Country: United States
Phone: (314) 362-0362
Fax: (314) 362-7855
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
My lab is interested in mechanisms of growth control and morpohogenesis. We use the development of the adult melanocyte stripes and growth and regeneration of the adult fins to study growth control in the intact animal. In addition, we develop and share mapping methods and tools that facilitate cloning of genes, including the standard haploid mapping panel, multiply marked chromosomes, and inbred mapping strains (including SJD and C32).


PUBLICATIONS
Dardis, G., Tryon, R., Ton, Q., Johnson, S.L., Iovine, M.K. (2017) Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. Developmental dynamics : an official publication of the American Association of Anatomists. 246(9):691-699
Merrick Schill, E., Lake, J.I., Tusheva, O.A., Nagy, N., Bery, S.K., Foster, L., Avetisyan, M., Johnson, S.L., Stenson, W.F., Goldstein, A.M., Heuckeroth, R.O. (2016) Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Developmental Biology. 409(2):473-88
Enright, J.M., Toomey, M.B., Sato, S.Y., Temple, S.E., Allen, J.R., Fujiwara, R., Kramlinger, V.M., Nagy, L.D., Johnson, K.M., Xiao, Y., How, M.J., Johnson, S.L., Roberts, N.W., Kefalov, V.J., Guengerich, F.P., Corbo, J.C. (2015) Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Current biology : CB. 25(23):3048-57
Zeng, Z., Johnson, S.L., Lister, J.A., Patton, E.E. (2015) Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish. Pigment cell & melanoma research. 28(2):229-32
Lee, H.J., Lowdon, R.F., Maricque, B., Zhang, B., Stevens, M., Li, D., Johnson, S.L., Wang, T. (2015) Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos. Nature communications. 6:6315
Tryon, R.C., Johnson, S.L. (2014) Clonal Analysis of kit ligand a Functional Expression Reveals Lineage-Specific Competence to Promote Melanocyte Rescue in the Mutant Regenerating Caudal Fin. PLoS One. 9:e102317
Cox, J.A., Lamora, A., Johnson, S.L., and Voigt, M.M. (2014) Novel role for carbamoyl phosphate synthetase 2 in cranial sensory circuit formation. Int. J. Dev. Neurosci.. 33C:41-48
Gray, R.S., Wilm, T.P., Smith, J., Bagnat, M., Dale, R.M., Topczewski, J., Johnson, S.L., and Solnica-Krezel, L. (2014) Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Developmental Biology. 386(1):72-85
Perathoner, S., Daane, J.M., Henrion, U., Seebohm, G., Higdon, C.W., Johnson, S.L., Nüsslein-Volhard, C., and Harris, M.P. (2014) Bioelectric signaling regulates size in zebrafish fins. PLoS Genetics. 10(1):e1004080
Higdon, C.W., Mitra, R.D., and Johnson, S.L. (2013) Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS One. 8(7):e67801
Tryon, R.C., Pisat, N., Johnson, S.L., and Dougherty, J.D. (2013) Development of translating ribosome affinity purification for zebrafish. Genesis (New York, N.Y. : 2000). 51(3):187-192
O'Reilly-Pol, T., and Johnson, S.L. (2013) Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos. Development (Cambridge, England). 140(5):996-1002
Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K.L., Temperley, N.D., Johnson, S.L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E.M., Melton, D.W., Smith, T.K., Tyers, M., Westwood, N.J., and Patton, E.E. (2012) ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Chemistry & Biology. 19(7):883-892
Petrey, A.C., Flanagan-Steet, H., Johnson, S., Fan, X., De la Rosa, M., Haskins, M.E., Nairn, A.V., Moremen, K.W., and Steet, R. (2012) Excessive activity of cathepsin K is associated with the cartilage defects in a zebrafish model for mucolipidosis II. Disease models & mechanisms. 5(2):177-190
Tryon, R.C., and Johnson, S.L. (2012) Clonal and lineage analysis of melanocyte stem cells and their progeny in the zebrafish. Meth. Mol. Biol.. 916:181-195
Tsetskhladze, Z.R., Canfield, V.A., Ang, K.C., Wentzel, S.M., Reid, K.P., Berg, A.S., Johnson, S.L., Kawakami, K., and Cheng, K.C. (2012) Functional assessment of human coding mutations affecting skin pigmentation using zebrafish. PLoS One. 7(10):e47398
Cox, J.A., McAdow, A.R., Dinitz, A.E., McCallion, A.S., Johnson, S.L., and Voigt, M.M. (2011) A zebrafish SKIV2L2-enhancer trap line provides a useful tool for the study of peripheral sensory circuit development. Gene Expression Patterns. 11(7):409-14
Cox, J.A., Lamora, A., Johnson, S.L., and Voigt, M.M. (2011) Diverse mechanisms for assembly of branchiomeric nerves. Developmental Biology. 357(2):305-17
Prasad, M.K., Reed, X., Gorkin, D.U., Cronin, J.C., McAdow, A.R., Chain, K., Hodonsky, C.J., Jones, E.A., Svaren, J.P., Antonellis, A., Johnson, S.L., Loftus, S.K., Pavan, W.J., and McCallion, A.S. (2011) SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer. BMC Developmental Biology. 11(1):40
Tu, S., and Johnson, S.L. (2011) Fate restriction in the growing and regenerating zebrafish fin. Developmental Cell. 20(5):725-732
Johnson, S.L., Nguyen, A.N., and Lister, J.A. (2011) mitfa is required at multiple stages of melanocyte differentiation but not to establish the melanocyte stem cell. Developmental Biology. 350(2):405-413
Tryon, R.C., Higdon, C.W., and Johnson, S.L. (2011) Lineage relationship of direct-developing melanocytes and melanocyte stem cells in the zebrafish. PLoS One. 6(6):e21010
Tu, S., and Johnson, S.L. (2010) Clonal analyses reveal roles of organ founding stem cells, melanocyte stem cells and melanoblasts in establishment, growth and regeneration of the adult zebrafish fin. Development (Cambridge, England). 137(23):3931-3939
Talbot, J.C., Johnson, S.L., and Kimmel, C.B. (2010) hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development (Cambridge, England). 137(15):2507-2517
Johnson, S. (2010) Transgenic Line Submissions. ZFIN Direct Data Submission.
Hultman, K.A., and Johnson, S.L. (2010) Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern. Developmental Biology. 337(2):425-431
Lang, M.R., Patterson, L.B., Gordon, T.N., Johnson, S.L., and Parichy, D.M. (2009) Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genetics. 5(11):e1000744
Green, J., Taylor, J.J., Hindes, A., Johnson, S.L., and Goldsmith, M.I. (2009) A gain of function mutation causing skeletal overgrowth in the rapunzel mutant. Developmental Biology. 334(1):224-234
Huang, C.C., Wang, T.C., Lin, B.H., Wang, Y.W., Johnson, S.L., and Yu, J. (2009) Collagen IX is Required for the Integrity of Collagen II Fibrils and the Regulation of Vascular Plexus Formation in Zebrafish Caudal Fins. Developmental Biology. 332(2):360-370
Hultman, K.A., Budi, E.H., Teasley, D.C., Gottlieb, A.Y., Parichy, D.M., and Johnson, S.L. (2009) Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genetics. 5(7):e1000544
Burgess, H.A., Johnson, S.L., and Granato, M. (2009) Unidirectional startle responses and disrupted left-right co-ordination of motor behaviors in robo3 mutant zebrafish. Genes, brain, and behavior. 8(5):500-511
O'Reilly-Pol, T., and Johnson, S.L. (2009) Melanocyte regeneration reveals mechanisms of adult stem cell regulation. Seminars in Cell & Developmental Biology. 20(1):117-124
O'Reilly-Pol, T., and Johnson, S.L. (2008) Neocuproine ablates melanocytes in adult zebrafish. Zebrafish. 5(4):257-264
Hultman, K.A., Scott, A.W., and Johnson, S.L. (2008) Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes. Zebrafish. 5(4):279-287
Lopes, S.S., Yang, X., Müller, J., Carney, T.J., McAdow, A.R., Rauch, G.J., Jacoby, A.S., Hurst, L.D., Delfino-Machín, M., Haffter, P., Geisler, R., Johnson, S.L., Ward, A., and Kelsh, R.N. (2008) Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics. 4(3):e1000026
Sheets, L., Ransom, D.G., Mellgren, E.M., Johnson, S.L., and Schnapp, B.J. (2007) Zebrafish Melanophilin Facilitates Melanosome Dispersion by Regulating Dynein. Current biology : CB. 17(20):1721-1734
Gansner, J.M., Mendelsohn, B.A., Hultman, K.A., Johnson, S.L., and Gitlin, J.D. (2007) Essential role of lysyl oxidases in notochord development. Developmental Biology. 307(2):202-213
Yang, C.T., Hindes, A.E., Hultman, K.A., and Johnson, S.L. (2007) Mutations in gfpt1 and skiv2l2 Cause Distinct Stage-Specific Defects in Larval Melanocyte Regeneration in Zebrafish. PLoS Genetics. 3(6):e88
Leslie, J.D., Ariza-McNaughton, L., Bermange, A.L., McAdow, R., Johnson, S.L., and Lewis, J. (2007) Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development (Cambridge, England). 134(5):839-844
Hultman, K.A., Bahary, N., Zon, L.I., and Johnson, S.L. (2007) Gene Duplication of the zebrafish kit ligand and partitioning of melanocyte development functions to kit ligand a. PLoS Genetics. 3(1):e17
Iwashita, M., Watanabe, M., Ishii, M., Chen, T., Johnson, S.L., Kurachi, Y., Okada, N., and Kondo, S. (2006) Pigment pattern in jaguar/obelix zebrafish is caused by a Kir7.1 mutation: implications for the regulation of melanosome movement. PLoS Biology. 2(11):e197
Yang, C.T., and Johnson, S.L. (2006) Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes. Development (Cambridge, England). 133(18):3563-3573
Goldsmith, M.I., Iovine, M.K., O'reilly-Pol, T., and Johnson, S.L. (2006) A developmental transition in growth control during zebrafish caudal fin development. Developmental Biology. 296(2):450-457
Mendelsohn, B.A., Yin, C., Johnson, S.L., Wilm, T.P., Solnica-Krezel, L., and Gitlin, J.D. (2006) Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metabolism. 4(2):155-162
Mellgren, E.M., and Johnson, S.L. (2006) pyewacket, a new zebrafish fin pigment pattern mutant. Pigment Cell Res.. 19(3):232-238
Guryev, V., Koudijs, M.J., Berezikov, E., Johnson, S.L., Plasterk, R.H., van Eeden, F.J., and Cuppen, E. (2006) Genetic variation in the zebrafish. Genome research. 16(4):491-497
Mellgren, E.M., and Johnson, S.L. (2005) kitb, a second zebrafish ortholog of mouse Kit. Development genes and evolution. 215(9):1-8
Iovine, M.K., Higgins, E.P., Hindes, A., Coblitz, B., and Johnson, S.L. (2005) Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Developmental Biology. 278(1):208-219
Yang, C.T., Sengelmann, R.D., and Johnson, S.L. (2004) Larval melanocyte regeneration following laser ablation in zebrafish. The Journal of investigative dermatology. 123(5):924-929
Mellgren, E.M., and Johnson, S.L. (2004) A requirement for kit in embryonic zebrafish melanocyte differentiation is revealed by melanoblast delay. Development genes and evolution. 214(10):493-502
Huang, C., Lawson, N.D., Weinstein, B.M., and Johnson, S.L. (2003) reg6 is required for branching morphogenesis during blood vessel regeneration in zebrafish caudal fins. Developmental Biology. 264(1):263-274
Rawls, J.F. and Johnson, S.L. (2003) Temporal and molecular separation of the kit receptor tyrosine kinase's roles in zebrafish melanocyte migration and survival. Developmental Biology. 262(1):152-161
Goldsmith, M.I., Fisher, S., Waterman, R., and Johnson, S.L. (2003) Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants. Developmental Biology. 259(2):303-317
Nechiporuk, A., Poss, K.D., Johnson, S.L., and Keating, M.T. (2003) Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. Developmental Biology. 258(2):291-306
Rawls, J.F., Frieda, M.R., McAdow, A.R., Gross, J.P., Clayton, C.M., Heyen, C.K., and Johnson, S.L. (2003) Coupled mutagenesis screens and genetic mapping in zebrafish. Genetics. 163(3):997-1009
Poss, K.D., Nechiporuk, A., Hillam, A.M., Johnson, S.L., and Keating, M.T. (2002) Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development (Cambridge, England). 129(22):5141-5149
Iovine, M.K., and Johnson, S.L. (2002) A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Genomics. 79(6):756-759
Mellgren, E.M. and Johnson, S.L. (2002) The evolution of morphological complexity in zebrafish stripes. Trends in genetics : TIG. 18(3):128-134
Rawls, J.F., Mellgren, E.M., and Johnson, S.L. (2001) How the zebrafish gets its stripes. Developmental Biology. 240(2):301-314
Hukriede, N., Fisher, D., Epstein, J., Joly, L., Tellis, P., Zhou, Y., Barbazuk, B., Cox, K., Fenton-Noriega, L., Hersey, C., Miles, J., Sheng, X., Song, A., Waterman, R., Johnson, S.L., Dawid, I.B., Chevrette, M., Zon, L.I., McPherson, J., and Ekker, M. (2001) The LN54 radiation hybrid map of zebrafish expressed sequences. Genome research. 11(12):2127-2132
Oates, A.C., Pratt, S.J., Vail, B., Yan, Y.-L., Ho, R.K., Johnson, S.L., Postlethwait, J.H., and Zon, L.I. (2001) The zebrafish klf gene family. Blood. 98(6):1792-1801
Clark, M.D., Hennig, S., Herwig, R., Clifton, S.W., Marra, M.A., Lehrach, H., Johnson, S.L., and Group, T.W. (2001) An oligonucleotide fingerprint normalized and expressed sequence tag characterized zebrafish cDNA library. Genome research. 11(9):1594-1602
Parichy, D.M. and Johnson, S.L. (2001) Zebrafish hybrids suggest genetic mechanisms for pigment pattern diversification in Danio. Development genes and evolution. 211(7):319-328
Rawls, J.F. and Johnson, S.L. (2001) Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes. Development (Cambridge, England). 128(11):1943-1949
Parichy, D.M., Mellgren, E.M., Rawls, J.F., Lopes, S.S., Kelsh, R.N., and Johnson, S.L. (2000) Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Developmental Biology. 227(2):294-306
Jagadeeswaran, P., Gregory, M., Johnson, S., and Thankavel, B. (2000) Haemostatic screening and identification of zebrafish mutants with coagulation pathway defects: an approach to identifying novel haemostatic genes in man. British journal of haematology. 110(4):946-956
Rawls, J.F. and Johnson, S.L. (2000) Zebrafish kit mutation reveals primary and secondary regulation of melanocyte development during fin stripe regeneration. Development (Cambridge, England). 127(17):3715-3724
Barbazuk, W.B., Korf, I., Kadavi, C., Heyen, J., Tate, S., Wun, E., Bedell, J.A., McPherson, J.D., and Johnson, S.L. (2000) The syntenic relationship of the zebrafish and human genomes. Genome research. 10(9):1351-1358
Parichy, D.M., Ransom, D.G., Paw, B., Zon, L.I., and Johnson, S.L. (2000) An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development (Cambridge, England). 127(14):3031-3044
Iovine, M.K. and Johnson, S.L. (2000) Genetic analysis of isometric growth control mechanisms in the zebrafish caudal fin. Genetics. 155(3):1321-1329
Kelly, P.D., Chu, F., Woods, I.G., Ngo-Hazelett, P., Cardozo, T., Huang, H., Kimm, F., Liao, L., Yan, Y.L., Zhou, Y., Johnson, S.L., Abagyan, R., Schier, A.F., Postlethwait, J.H., and Talbot, W.S. (2000) Genetic linkage mapping of zebrafish genes and ESTs. Genome research. 10(4):558-567
Nechiporuk, A., Finney, J.E., Keating, M.T., and Johnson, S.L. (1999) Assessment of polymorphism in zebrafish mapping strains. Genome research. 9(12):1231-1238
Oates, A.C., Brownlie, A., Pratt, S.J., Irvine, D.V., Liao, E.C., Paw, B.H., Dorian, K.J., Johnson, S.L., Postlethwait, J.H., Zon, L.I., and Wilks, A.F. (1999) Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expresssion patterns: only jak2a is expressed during erythropoiesis. Blood. 94(8):2622-2636
Lister, J.A., Robertson, C.P., Lepage, T., Johnson, S.L., and Raible, D.W. (1999) nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate. Development (Cambridge, England). 126(17):3757-3767
Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proc. Natl. Acad. Sci. USA. 96(17):9745-9750
Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436
Johnson, S.L. and Zon, L.I. (1999) Genetic backgrounds and some standard stocks and strains used in zebrafish developmental biology and genetics. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:357-359
Johnson, S.L. and Bennett, P. (1999) Growth control in the ontogenetic and regenerating zebrafish fin. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:301-311
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349
Lee, K.H., Marden, J.J., Thompson, M.S., MacLennan, H., Kishimoto, Y., Pratt, S.J., Schulte-Merker, S., Hammerschmidt, M., Johnson, S.L., Postlethwait, J.H., Beier, D.C., and Zon, L.I. (1998) Cloning and genetic mapping of zebrafish BMP-2. Developmental genetics. 23:97-103
Bingulac-Popovic, J., Figueroa, F., Sato, A., Talbot, W.S., Johnson, S.L., Gates, M., Postlethwait, J.H., and Klein, J. (1997) Mapping of Mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio. Immunogenetics. 46(2):129-134
Johnson, S.L., Gates, M.A., Johnson, M., Talbot, W.S., Horne, S., Baik, K., Rude, S., Wong, J.R., and Postlethwait, J.H. (1996) Centromere-linkage analysis and consolidation of the zebrafish genetic map. Genetics. 142:1277-1288
Johnson, S.L. and Weston, J.A. (1995) Temperature-sensitive mutations that cause stage-specific defects in Zebrafish fin regeneration. Genetics. 141:1583-1595
Kauffman, E.J., Gestl, E.E., Kim, D.J., Walker, C., Hite, J.M., Yan, G., Rogan, P.K., Johnson, S.L., and Cheng, K.C. (1995) Microsatellite-centromere mapping in the zebrafish (Danio rerio). Genomics. 30:337-341
Johnson, S.L., Africa, D., Horne, S., and Postlethwait, J.H. (1995) Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I. Genetics. 139:1727-1737
Akimenko, M.A., Johnson, S.L., Westerfield, M., and Ekker, M. (1995) Differential induction of four msx homeobox genes during fin development and regeneration in zebrafish. Development (Cambridge, England). 121:347-357
Johnson, S.L., Africa, D., Walker, C., and Weston, J.A. (1995) Genetic control of adult pigment stripe development in zebrafish. Developmental Biology. 167:27-33
Postlethwait, J., Johnson, S., Midson, C.N., Talbot, W.S., Gates, M., Ballenger, E.W., Africa, D., Andrews, R., Carl, T., Eisen, J.S., Horne, S., Kimmel, C.B., Hutchinson, M., Johnson, M., and Rodriguez, A. (1994) A genetic linkage map for the zebrafish. Science (New York, N.Y.). 264:699-703
Johnson, S.L., Midson, C.N., Ballenger, E.W., and Postlethwait, J.H. (1994) Identification of RAPD primers that reveal extensive polymorphisms between laboratory strains of zebrafish. Genomics. 19:152-156

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