PUBLICATION
Larval melanocyte regeneration following laser ablation in zebrafish
- Authors
- Yang, C.T., Sengelmann, R.D., and Johnson, S.L.
- ID
- ZDB-PUB-041018-1
- Date
- 2004
- Source
- The Journal of investigative dermatology 123(5): 924-929 (Journal)
- Registered Authors
- Johnson, Stephen L., Yang, Chao-Tsung
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Division/physiology
- Lasers
- Melanocytes/cytology*
- Melanocytes/physiology*
- Proto-Oncogene Proteins c-kit/physiology
- Regeneration/physiology*
- Skin/cytology
- Skin/growth & development
- Skin Physiological Phenomena*
- Skin Pigmentation/physiology
- Zebrafish
- PubMed
- 15482481 Full text @ J. Invest. Dermatol.
Citation
Yang, C.T., Sengelmann, R.D., and Johnson, S.L. (2004) Larval melanocyte regeneration following laser ablation in zebrafish. The Journal of investigative dermatology. 123(5):924-929.
Abstract
A method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping