ZFIN ID: ZDB-PUB-041018-1
Larval melanocyte regeneration following laser ablation in zebrafish
Yang, C.T., Sengelmann, R.D., and Johnson, S.L.
Date: 2004
Source: The Journal of investigative dermatology 123(5): 924-929 (Journal)
Registered Authors: Johnson, Stephen L., Yang, Chao-Tsung
Keywords: none
MeSH Terms: Animals; Cell Division/physiology; Lasers; Melanocytes/cytology*; Melanocytes/physiology* (all 12) expand
PubMed: 15482481 Full text @ J. Invest. Dermatol.
A method to specifically ablate melanocytes in a genetically tractable organism would facilitate the analysis of melanocyte regeneration and regulation. We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology laser kills larval melanocytes in zebrafish. Following melanocyte ablation, new melanocytes regenerate from unpigmented precursors. We show that melanocyte regeneration following laser ablation requires kit receptor tyrosine kinase.