ZFIN ID: ZDB-PUB-001017-3
The syntenic relationship of the zebrafish and human genomes
Barbazuk, W.B., Korf, I., Kadavi, C., Heyen, J., Tate, S., Wun, E., Bedell, J.A., McPherson, J.D., and Johnson, S.L.
Date: 2000
Source: Genome research 10(9): 1351-1358 (Journal)
Registered Authors: Johnson, Stephen L., Kadavi, Candy Ann
Keywords: none
MeSH Terms: Animals; Chromosome Mapping; Chromosomes, Human/genetics; Conserved Sequence; Expressed Sequence Tags (all 10) expand
PubMed: 10984453 Full text @ Genome Res.
ABSTRACT
The zebrafish is an important vertebrate model for the mutational analysis of genes effecting developmental processes. Understanding the relationship between zebrafish genes and mutations with those of humans will require understanding the syntenic correspondence between the zebrafish and human genomes. High throughput gene and EST mapping projects in zebrafish are now facilitating this goal. Map positions for 523 zebrafish genes and ESTs with predicted human orthologs reveal extensive contiguous blocks of synteny between the zebrafish and human genomes. Eighty percent of genes and ESTs analyzed belong to conserved synteny groups (two or more genes linked in both zebrafish and human) and 56% of all genes analyzed fall in 118 homology segments (uninterrupted segments containing two or more contiguous genes or ESTs with conserved map order between the zebrafish and human genomes). This work now provides a syntenic relationship to the human genome for the majority of the zebrafish genome.
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