ZFIN Person: Thisse, Bernard

ZFIN ID: ZDB-PERS-960805-556

ZFIN ID: ZDB-PERS-960805-556

Thisse, Bernard (Deceased)

Email:	bernardthisse@virginia.edu
URL:
Affiliation:	Thisse's Lab
Address:	Department of Cell Biology School of Medicine University of Virginia School of Medicine 1300 Jefferson Park Avenue Charlottesville, VA 22903 USA
Country:	United States
Phone:	(434) 243-6613
Fax:	(434) 982-3390
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Research interest: my goal is to understand the molecular mechanisms that control the formation of the early vertebrate embryo. The following questions are currently addressed: how molecular signals from maternal or zygotic origins control the fate of early embryonic cells; how these signals interact with each other to define embryonic germ layers and control their regionalization into organs, tissues and cell types; how molecular signals generate organizer activities that control the initial formation of the embryo. Our long term goal is to identify how naïve, early embryonic blastomeres with stem cell properties can be directed toward the formation of complete tissues and organs in a vertebrate organism.

Representative Publications

Lu, F.I., Thisse, C., and Thisse, B. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant Proc. Natl. Acad. Sci. USA 108(38):15876-80.

Fauny, J-D., Thisse, B. and Thisse, C. (2009). The entire zebrafish blastula/gastrula margin acts as an organizer dependent on the ratio of Nodal/BMP activity. Development. 136 :3811-3819.

Seiliez, I., Thisse, B. and Thisse, C. (2006) FoxA3 and Goosecoid Promote Anterior Neural Fate through Inhibition of Wnt8a Activity Before the Onset of Gastrulation Dev. Biol. 290, 152-163.

Fürthauer, M., Van Celst, Thisse, C. and Thisse, B (2004). FGF signalling controls the Dorso-Ventral patterning of the zebrafish embryo. Development. 131, 2853-2864

Agathon, A., Thisse, C. and Thisse, B. (2003). The molecular nature of the zebrafish tail organizer. Nature. 424 : 448-452.

Fürthauer, M, Lin, W., Ang, S-L., Thisse, B. and Thisse, C. (2002). Sef acts as a novel feedback induced antagonist of FGF signaling. Nat. Cell Biol. 4, 170-174.

Thisse, B., Wright, C. V. E. and Thisse, C. (2000) Activin and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403, 425-427.

PUBLICATIONS

Rothschild, S.C., Ingram, S.R., Lu, F.I., Thisse, B., Thisse, C., Parkerson, J.A., Tombes, R.M. (2020) Genetic compensation of γ CaMKII, an evolutionarily conserved gene. Gene. 742:144567

Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:

de Olivera-Melo, M., Xu, P.F., Houssin, N., Thisse, B., Thisse, C. (2018) Generation of Ectopic Morphogen Gradients in the Zebrafish Blastula. Methods in molecular biology (Clifton, N.J.). 1863:125-141

Naylor, R.W., Skvarca, L.B., Thisse, C., Thisse, B., Hukriede, N.A., Davidson, A.J. (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nature communications. 7:12197

Fang, X., Zhang, B., Thisse, B., Bloom, G.S., Thisse, C. (2015) IQGAP3 Is Essential for Cell Proliferation and Motility During Zebrafish Embryonic Development. Cytoskeleton (Hoboken, N.J.). 72(8):422-33

Thisse, B., Thisse, C. (2015) Formation of the Vertebrate Embryo: Moving Beyond the Spemann Organizer. Seminars in cell & developmental biology. 42:94-102

Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27

Lu, F.I., Sun, Y.H., Wei, C.Y., Thisse, C., Thisse, B. (2014) Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications. 5:5368

Thisse, B., Thisse, C. (2014) [Construction of a vertebrate embryo from two morphogen gradients]. Medecine sciences : M/S. 30:739-42

deCarvalho, T.N., Subedi, A., Rock, J., Harfe, B.D., Thisse, C., Thisse, B., Halpern, M.E., Hong, E. (2014) Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (New York, N.Y. : 2000). 52(6):636-55

Xu, P.F., Houssin, N., Ferri-Lagneau, K.F., Thisse, B., Thisse, C. (2014) Construction of a vertebrate embryo from two opposing morphogen gradients. Science (New York, N.Y.). 344:87-9

Thisse, B., Thisse, C. (2014) In Situ Hybridization on Whole-Mount Zebrafish Embryos and Young Larvae. Methods in molecular biology (Clifton, N.J.). 1211:53-67

Hong, E., Santhakumar, K., Akitake, C.A., Ahn, S.J., Thisse, C., Thisse, B., Wyart, C., Mangin, J.M., and Halpern, M.E. (2013) Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proceedings of the National Academy of Sciences of the United States of America. 110(52):21171-21176

Yuen, M.Y., Webb, S.E., Chan, C.M., Thisse, B., Thisse, C., and Miller, A.L. (2013) Characterization of Ca(2+) signaling in the external yolk syncytial layer during the late blastula and early gastrula periods of zebrafish development. Biochimica et biophysica acta. Molecular cell research. 1833(7):1641-56

deCarvalho, T.N., Akitake, C.M., Thisse, C., Thisse, B., Halpern, M.E. (2013) Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Frontiers in neural circuits. 7:98

Li, Q., Frank, M., Akiyama, M., Shimizu, H., Ho, S.Y., Thisse, C., Thisse, B., Sprecher, E., and Uitto, J. (2011) Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Disease models & mechanisms. 4(6):777-85

Lu, F.I., Thisse, C., and Thisse, B. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15876-80

Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J. (2011) Zebrafish: A Model System to Study Heritable Skin Diseases. The Journal of investigative dermatology. 131(3):565-571

Dal-Pra, S., Thisse, C., and Thisse, B. (2011) FoxA transcription factors are essential for the development of dorsal axial structures. Developmental Biology. 350(2):484-495

Petit, D., Mir, A., Petit, J., Thisse, C., Delannoy, P., Oriol, R., Thisse, B., Harduin-Lepers, A. (2010) Molecular phylogeny and functional genomics of beta-galactoside alpha2,6-sialyltransferases that explain ubiquitous expression of st6gal1 gene in amniotes. The Journal of biological chemistry. 285:38399-38414

Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677

Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665

Li, Q., Sadowski, S., Frank, M., Chai, C., Váradi, A., Ho, S.Y., Lou, H., Dean, M., Thisse, C., Thisse, B., and Uitto, J. (2010) The abcc6a Gene Expression Is Required for Normal Zebrafish Development. The Journal of investigative dermatology. 130(11):2561-2568

Belliveau, D.J., Venkatachalam, A.B., Thisse, C., Thisse, B., Ma, H., and Wright, J.M. (2010) The duplicated retinol-binding protein 7 (rbp7) genes are differentially transcribed in embryos and adult zebrafish (Danio rerio). Gene expression patterns : GEP. 10(4-5):167-176

Karanth, S., Denovan-Wright, E.M., Thisse, C., Thisse, B., and Wright, J.M. (2009) Tandem duplication of the fabp1b gene and subsequent divergence of the tissue-specific distribution of fabp1b.1 and fabp1b.2 transcripts in zebrafish (Danio rerio). Genome. 52(12):985-992

Fauny, J.D., Thisse, B., and Thisse, C. (2009) The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. Development (Cambridge, England). 136(22):3811-3819

Venkatachalam, A.B., Thisse, C., Thisse, B., and Wright, J.M. (2009) Differential tissue-specific distribution of transcripts for the duplicated fatty acid-binding protein 10 (fabp10) genes in embryos, larvae and adult zebrafish (Danio rerio). The FEBS journal. 276(22):6787-6797

Chang, L.Y., Mir, A.M., Thisse, C., Guérardel, Y., Delannoy, P., Thisse, B., and Harduin-Lepers, A. (2009) Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Glycoconjugate journal. 26(3):263-275

Boehmler, W., Petko, J., Woll, M., Frey, C., Thisse, B., Thisse, C., Canfield, V.A., and Levenson, R. (2009) Identification of zebrafish A2 adenosine receptors and expression in developing embryos. Gene expression patterns : GEP. 9(3):144-151

Alves-Costa, F.A., Denovan-Wright, E.M., Thisse, C., Thisse, B., and Wright, J.M. (2008) Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio). The FEBS journal. 275(13):3325-3334

Karanth, S., Denovan-Wright, E.M., Thisse, C., Thisse, B., and Wright, J.M. (2008) The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes. The FEBS journal. 275(12):3031-3040

Pagnon-Minot, A., Malbouyres, M., Haftek-Terreau, Z., Kim, H.R., Sasaki, T., Thisse, C., Thisse, B., Ingham, P.W., Ruggiero, F., and Le Guellec, D. (2008) Collagen XV, a novel factor in zebrafish notochord differentiation and muscle development. Developmental Biology. 316(1):21-35

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2008) Combinatorial regulation of novel erythroid gene expression in zebrafish. Experimental hematology. 36(4):424-432

Thisse, B., Wright, G.J., Thisse, C. (2008) Embryonic and Larval Expression Patterns from a Large Scale Screening for Novel Low Affinity Extracellular Protein Interactions. ZFIN Direct Data Submission.

Thisse, C., and Thisse, B. (2008) Expression from: Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. ZFIN Direct Data Submission.

Thisse, C., and Thisse, B. (2008) High-resolution in situ hybridization to whole-mount zebrafish embryos. Nature Protocols. 3(1):59-69

Bertrand, S., Thisse, B., Tavares, R., Sachs, L., Chaumot, A., Bardet, P.L., Escrivà, H., Duffraisse, M., Marchand, O., Safi, R., Thisse, C., and Laudet, V. (2007) Unexpected Novel Relational Links Uncovered by Extensive Developmental Profiling of Nuclear Receptor Expression. PLoS Genetics. 3(11):e188

Wingert, R.A., Selleck, R., Yu, J., Song, H.D., Chen, Z., Song, A., Zhou, Y., Thisse, B., Thisse, C., McMahon, A.P., and Davidson, A.J. (2007) The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. PLoS Genetics. 3(10):1922-1938

Stetsyuk, V., Peers, B., Mavropoulos, A., Verbruggen, V., Thisse, B., Thisse, C., Motte, P., Duvillie, B., and Scharfmann, R. (2007) Calsenilin is required for endocrine pancreas development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 236(6):1517-1525

Li, P., Shah, S., Huang, L., Carr, A.L., Gao, Y., Thisse, C., Thisse, B., and Li, L. (2007) Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Developmental dynamics : an official publication of the American Association of Anatomists. 236(5):1339-1346

Kikuta, H., Laplante, M., Navratilova, P., Komisarczuk, A.Z., Engstrom, P.G., Fredman, D., Akalin, A., Caccamo, M., Sealy, I., Howe, K., Ghislain, J., Pezeron, G., Mourrain, P., Ellingsen, S., Oates, A.C., Thisse, C., Thisse, B., Foucher, I., Adolf, B., Geling, A., Lenhard, B., and Becker, T.S. (2007) Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome research. 17(5):545-555

Boehmler, W., Carr, T., Thisse, C., Thisse, B., Canfield, V.A., and Levenson, R. (2007) D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes, brain, and behavior. 6(2):155-166

Liu, R.Z., Saxena, V., Sharma, M.K., Thisse, C., Thisse, B., Denovan-Wright, E.M.,Wright, J.M. (2007) The fabp4 gene of zebrafish (Danio rerio)--genomic homology with the mammalian FABP4 and divergence from the zebrafish fabp3 in developmental expression. The FEBS journal. 274(6):1621-1633

Huang, H., Lu, F.I., Jia, S., Meng, S., Cao, Y., Wang, Y., Ma, W., Yin, K., Wen, Z., Peng, J., Thisse, C., Thisse, B., and Meng, A. (2007) Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development (Cambridge, England). 134(5):979-988

Deniziak, M., Thisse, C., Rederstorff, M., Hindelang, C., Thisse, B., and Lescure, A. (2007) Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Experimental cell research. 313(1):156-167

Dal-Pra, S., Fürthauer, M., Van-Celst, J., Thisse, B., and Thisse, C. (2006) Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Developmental Biology. 298(2):514-526

Hu, G., Tang, J., Zhang, B., Lin, Y., Hanai, J.I., Galloway, J., Bedell, V., Bahary, N., Han, Z., Ramchandran, R., Thisse, B., Thisse, C., Zon, L.I., and Sukhatme, V.P. (2006) A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. Journal of Cell Science. 119(Pt 19):4117-4126

Sharma, M.K., Liu, R.Z., Thisse, C., Thisse, B., Denovan-Wright, E.M., and Wright, J.M. (2006) Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome. The FEBS journal. 273(14):3216-3229

Poulain, M., Fürthauer, M., Thisse, B., Thisse, C., and Lepage, T. (2006) Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling. Development (Cambridge, England). 133(11):2189-2200

Pujic, Z., Omori, Y., Tsujikawa, M., Thisse, B., Thisse, C., and Malicki, J. (2006) Reverse genetic analysis of neurogenesis in the zebrafish retina. Developmental Biology. 293(2):330-347

Tang, J., Hu, G., Hanai, J.I., Yadlapalli, G., Lin, Y., Zhang, B., Galloway, J., Bahary, N., Sinha, S., Thisse, B., Thisse, C., Jin, J.P., Zon, L.I., and Sukhatme, V.P. (2006) A critical role for calponin 2 in vascular development. The Journal of biological chemistry. 281(10):6664-6672

Seiliez, I., Thisse, B., and Thisse, C. (2006) FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Developmental Biology. 290(1):152-163

Croushore, J.A., Blasiole, B., Riddle, R.C., Thisse, C., Thisse, B., Canfield, V.A., Robertson, G.P., Cheng, K.C., and Levenson, R. (2005) Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 234(4):911-921

Gamse, J.T., Kuan, Y.S., Macurak, M., Brosamle, C., Thisse, B., Thisse, C., and Halpern, M.E. (2005) Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development (Cambridge, England). 132(21):4869-4881

Thisse, C., and Thisse, B. (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission.

Blasiole, B., Kabbani, N., Boehmler, W., Thisse, B., Thisse, C., Canfield, V., and Levenson, R. (2005) Neuronal calcium sensor-1 gene ncs-1a is essential for semicircular canal formation in zebrafish inner ear. Journal of neurobiology. 64(3):285-297

Blaser, H., Eisenbeiss, S., Neumann, M., Reichman-Fried, M., Thisse, B., Thisse, C., and Raz, E. (2005) Transition from non-motile behaviour to directed migration during early PGC development in zebrafish. Journal of Cell Science. 118(17):4027-4038

Liu, R.Z., Sharma, M.K., Sun, Q., Thisse, C., Thisse, B., Denovan-Wright, E.M., and Wright, J.M. (2005) Retention of the duplicated cellular retinoic acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish genome by subfunctionalization of tissue-specific expression. The FEBS journal. 272(14):3561-3571

Zhu, H., Traver, D., Davidson, A.J., Dibiase, A., Thisse, C., Thisse, B., Nimer, S., and Zon, L.I. (2005) Regulation of the lmo2 promoter during hematopoietic and vascular development in zebrafish. Developmental Biology. 281(2):256-269

Kedinger, V., Alpy, F., Tomasetto, C., Thisse, C., Thisse, B., and Rio, M.C. (2005) Spatial and temporal distribution of the traf4 genes during zebrafish development. Gene expression patterns : GEP. 5(4):545-552

Liu, R.Z., Sun, Q., Thisse, C., Thisse, B., Wright, J.M., and Denovan-Wright, E.M. (2005) The Cellular Retinol-Binding Protein Genes are Duplicated and Differentially Transcribed in the Developing and Adult Zebrafish (Danio rerio). Mol. Biol. Evol.. 22(3):469-477

Li, Q., Shirabe, K., Thisse, C., Thisse, B., Okamoto, H., Masai, I., and Kuwada, J.Y. (2005) Chemokine signaling guides axons within the retina in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(7):1711-1717

Sharma, M.K., Saxena, V., Liu, R.Z., Thisse, C., Thisse, B., Denovan-Wright, E.M., and Wright, J.M. (2005) Differential expression of the duplicated cellular retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during zebrafish embryonic development. Gene expression patterns : GEP. 5(3):371-379

Galloway, J.L., Wingert, R.A., Thisse, C., Thisse, B., and Zon, L.I. (2005) Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryos. Developmental Cell. 8(1):109-116

Daggett, D.F., Boyd, C.A,. Gautier, P., Bryson-Richardson, R.J., Thisse, C., Thisse, B., Amacher, S.L., and Currie, P.D. (2004) Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Current biology : CB. 14(18):632-638

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

Sharma, M.K., Denovan-Wright, E.M., Degrave, A., Thisse, C., Thisse, B., and Wright, J.M. (2004) Sequence, linkage mapping and early developmental expression of the intestinal-type fatty acid-binding protein gene (fabp2) from zebrafish (Danio rerio). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 138(4):391-398

Boehmler, W., Obrecht-Pflumio, S., Canfield, V., Thisse, C., Thisse, B., and Levenson, R. (2004) Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 230(3):481-493

Liu, R.Z., Denovan-Wright, E.M., Degrave, A., Thisse, C., Thisse, B., and Wright, J.M. (2004) Differential expression of duplicated genes for brain-type fatty acid-binding proteins (fabp7a and fabp7b) during early development of the CNS in zebrafish (Danio rerio). Gene expression patterns : GEP. 4(4):379-387

Fürthauer, M., Van Celst, J., Thisse, C., and Thisse, B. (2004) Fgf signalling controls the dorsoventral patterning of the zebrafish embryo. Development (Cambridge, England). 131(12):2853-2864

Bardet, P.L., Obrecht-Pflumio, S., Thisse, C., Laudet, V., Thisse, B., and Vanacker, J.M. (2004) Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish. Development genes and evolution. 214(5):240-249

Thisse, B., Heyer, V., Lux, A., Alunni, V., Degrave, A., Seiliez, I., Kirchner, J., Parkhill, J.P., and Thisse, C. (2004) Spatial and temporal expression of the zebrafish genome by large-scale in situ hybridization screening. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:505-519

Liu, R.Z., Denovan-Wright, E.M., Degrave, A., Thisse, C., Thisse, B., and Wright, J.M. (2004) Spatio-temporal distribution of cellular retinol-binding protein gene transcripts (CRBPI and CRBPII) in the developing and adult zebrafish (Danio rerio). European journal of biochemistry. 271(2):339-348

Blasiole, B., Degrave, A., Canfield, V., Boehmier, W., Thisse, C., Thisse, B., Mohideen, M.A., and Levenson, R. (2003) Differential expression of Na,K-ATPase alpha and beta subunit genes in the developing zebrafish inner ear. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):386-392

Weidinger, G., Stebler, J., Slanchev, K., Dumstrei, K., Wise, C., Lovell-Badge, R., Thisse, C., Thisse, B., and Raz, E. (2003) dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival. Current biology : CB. 13(16):1429-1434

Thisse, C., Degrave, A., Kryukov, G.V., Gladyshev, V.N., Obrecht-Pflumio, S., Krol, A., Thisse, B., and Lescure, A. (2003) Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene expression patterns : GEP. 3(4):525-532

Agathon, A., Thisse, C., and Thisse, B. (2003) The molecular nature of the zebrafish tail organizer. Nature. 424(6947):448-452

Delaunay, F., Thisse, C., Thisse, B., and Laudet, V. (2003) Differential regulation of Period 2 and Period 3 expression during development of the zebrafish circadian clock. Gene expression patterns : GEP. 3(3):319-324

Haftek, Z., Morvan-Dubois, G., Thisse, B., Thisse, C., Garrone, R., and Le Guellec, D. (2003) Sequence and embryonic expression of collagen XVIII NC1 domain (endostatin) in the zebrafish. Gene expression patterns : GEP. 3(3):351-354

Gamse, J.T., Thisse, C., Thisse, B., and Halpern, M.E. (2003) The parapineal mediates left-right asymmetry in the zebrafish diencephalon. Development (Cambridge, England). 130:1059-1068

Donovan, A., Brownlie, A., Dorschner, M., Zhou, Y., Pratt, S.J., Paw, B.H., Thisse, C., Thisse, B., and Zon, L.I. (2002) The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood. 100:4655-4659

David, N.B., Sapede, D., Saint-Etienne, L., Thisse, C., Thisse, B., Dambly-Chaudiere, C., Rosa, F.M., and Ghysen, A. (2002) Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1. Proceedings of the National Academy of Sciences of the United States of America. 99(25):16297-16302

Blasiole, B., Canfield, V., Degrave, A., Thisse, C., Thisse, B., Rajarao, J., and Levenson, R. (2002) Cloning, mapping, and developmental expression of a sixth zebrafish Na,K-ATPase alpha1 subunit gene (atp1a1a.5). Mechanisms of Development. (Suppl.) 119:S211-S214

Blasiole, B., Canfield, V., Degrave, A., Thisse, C., Thisse, B., Rajarao, J., and Levenson, R. (2002) RETRACTED: Cloning, mapping, and developmental expression of a sixth zebrafish Na,K-ATPase alpha1 subunit gene (atp1a1a.5). Gene expression patterns : GEP. 2(3-4):243-246

Ciruna, B., Weidinger, G., Knaut, H., Thisse, B., Thisse, C., Raz, E., and Schier, A.F. (2002) Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proceedings of the National Academy of Sciences of the United States of America. 99(23):14919-14924

Müller, K., Thisse, C., Thisse, B. and Raz, E. (2002) Expression of a linker histone-like gene in the primordial germ cells in zebrafish. Mechanisms of Development. 117:253-257

Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Postlethwait, J.H., Mohideen, A.P.K., Rajarao, S.J.R., and Levenson, R. (2002) Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis. Mechanisms of Development. 116(1-2):51-59

Rajarao, J.R., Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Yan, Y.-L., Postlethwait, J.H., and Levenson, R. (2002) Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 223(2):254-261

Malicki, J.J., Pujic, Z., Thisse, C., Thisse, B., and Wei, X. (2002) Forward and reverse genetic approaches to the analysis of eye development in zebrafish. Vision Research. 42(4):527-533

Fürthauer, M., Lin, W., Ang, S.L., Thisse, B., and Thisse, C. (2002) Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nature cell biology. 4(2):170-174

Gamse, J.T., Shen, Y.-C., Thisse, C., Thisse, B., Raymond, P.A., Halpern, M.E., and Liang, J.O. (2002) Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Nature Genetics. 30(1):117-121

Weidinger, G., Wolke, U., Köprunner, M., Thisse, C., Thisse, B. and Raz, E. (2002) Regulation of zebrafish primordial germ cell migration by attraction towards an intermediate target. Development (Cambridge, England). 129:25-36

Lecaudey, V., Thisse, C., Thisse, B., and Schneider-Maunoury, S. (2001) Sequence and expression pattern of ziro7, a novel, divergent zebrafish iroquois homeobox gene. Mechanisms of Development. 109(2):383-388

Davidson, A.J., Dooley, K., Schmidt, B., Paffett-Lugassy, N., White, N., Walderich, B., Odenthal, J., Maischein, H.M., Schulte-Merker, S., Nüsslein-Volhard, C., Thisse, C., Thisse, B., and Zon, L.I. (2001) Functional genomics and mutagenesis screening in the zebrafish identifies genes required for hematopoietic stem cell development. Blood. 98(11):1888

Belting, H.G., Hauptmann, G., Meyer, D., Abdelilah-Seyfried, S., Chitnis, A., Eschbach, C., Söll, I., Thisse, C., Thisse, B., Artinger, K., Lunde, K., and Driever, W. (2001) spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer. Development (Cambridge, England). 128(21):4165-4176

Köprunner, M., Thisse, C., Thisse, B., and Raz, E. (2001) A zebrafish nanos related gene is essential for the development of primordial germ cells. Genes & Development. 15(21):2877-2885

Herbomel, P., Thisse, B., and Thisse, C. (2001) Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Developmental Biology. 238(2):274-288

Thisse, B., Pflumio, S., Fürthauer, M., Loppin, B., Heyer, V., Degrave, A., Woehl, R., Lux, A., Steffan, T., Charbonnier, X.Q. and Thisse, C. (2001) Expression of the zebrafish genome during embryogenesis (NIH R01 RR15402). ZFIN Direct Data Submission.

Agathon, A., Thisse, B., and Thisse, C. (2001) Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling. Genesis (New York, N.Y. : 2000). 30(3):178-182

Gompel, N., Cubedo, N., Thisse, C., Thisse, B., Dambly-Chaudiere, C., and Ghysen, A. (2001) Pattern formation in the lateral line of zebrafish. Mechanisms of Development. 105(1-2):69-77

Weidinger, G., Koprunner, M., Wolke, U., Thisse, C., Thisse, B., and Raz, E. (2001) Attraction, active migration, and clustering of zebrafish primordial germ cells. Developmental Biology. 235(1):175 (#18)

Kikuchi, Y., Agathon, A., Alexander, J., Thisse, C., Waldron, S., Yelon, D., Thisse, B., and Stainier, D.Y. (2001) casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish. Genes & Development. 15(12):1493-1505

Fürthauer, M., Reifers, F., Brand, M., Thisse, B., and Thisse, C. (2001) sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish. Development (Cambridge, England). 128(12):2175-2186

Thisse, B., Thisse, C., and Laudet, V. (2001) Inherited circadian clock in zebrafish: the mother and her clock. Médecine Sciences. 17(3):365-368

Thaëron, C., Avaron, F., Casane, D., Borday, V., Thisse, B., Thisse, C., Boulekbache, H., and Laurenti, P. (2000) Zebrafish evx1 is dynamically expressed during embryogenesis in subsets of interneurones, posterior gut and urogenital system. Mechanisms of Development. 99(1-2):167-172

Neyt, C., Jagla, K., Thisse, C., Thisse, B., Haines, L., and Currie, P.D. (2000) Evolutionary origins of vertebrate appendicular muscle. Nature. 408(6808):82-86

Thisse, C., Neel, H., Thisse, B., Daujat, S., and Piette, J. (2000) The Mdm2 gene of zebrafish (Danio rerio): preferential expression during development of neural and muscular tissues, and absence of tumor formation after overexpression of its cDNA during early embryogenesis. Differentiation; research in biological diversity. 66(2-3):61-70

Delaunay, F., Thisse, C., Marchand, O., Laudet, V., and Thisse, B. (2000) An inherited functional circadian clock in zebrafish embryos. Science (New York, N.Y.). 289(5477):297-300

Poss, K.D., Shen, J., Nechiporuk, A., McMahon, G., Thisse, B., Thisse, C., and Keating, M.T. (2000) Roles for Fgf signaling during zebrafish fin regeneration. Developmental Biology. 222(2):347-358

Durbin, L., Sordino, P., Barrios, A., Gering, M., Thisse, C., Thisse, B., Brennan, C., Green, A., Wilson, S., and Holder, N. (2000) Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafish. Development (Cambridge, England). 127(8):1703-1713

Cheng, A.M.S., Thisse, B., Thisse, C., and Wright, C.V. (2000) The Lefty-related factor Xatv acts as a feedback inhibitor of Nodal signaling in mesoderm induction and L-R axis development in Xenopus. Development (Cambridge, England). 127(5):1049-1061

Schmid, B., Fürthauer, M., Connors, S.A., Trout, J., Thisse, B., Thisse, C., and Mullins, M.C. (2000) Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development (Cambridge, England). 127(5):957-967

Thisse, B., Wright, C.V.E., and Thisse, C. (2000) Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature. 403(6768):425-428

Brand, M., Lun, K., Reifers, F., Thisse, B., Thisse, C., Amores, A., Yan, Y.-L., and Postlethwait, J. (2000) Subdivision of the early zebrafish neural primordium in response to posteriorizing signals. The European journal of neuroscience. 12:60

Ishimaru, Y., Yoshioka, H., Tao, H., Thisse, B., Thisse, C., Wright, C.V.E., Hamada, H. Ohuchi, H., and Noji, S. (2000) Asymmetric expression of antivin/lefty1 in the early chick embryo. Mechanisms of Development. 90(1):115-118

Fürthauer, M., Thisse, B., and Thisse, C. (1999) Three different noggin genes antagonize the activity of bone morphogenetic proteins in the zebrafish embryo. Developmental Biology. 214(1):181-196

Miller-Bertoglio, V., Carmany-Rampey, A., Fürthauer, M., Gonzalez, E.M., Thisse, C., Thisse, B., Halpern, M.E., and Solnica-Krezel, L. (1999) Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Developmental Biology. 214(1):72-86

Herbomel, P., Thisse, B., and Thisse, C. (1999) Ontogeny and behaviour of early macrophages in the zebrafish embryo. Development (Cambridge, England). 126(17):3735-3745

Thisse, C. and Thisse, B. (1999) Antivin, a novel and divergent member of the TGFß superfamily, negatively regulates mesoderm induction. Development (Cambridge, England). 126:229-240

Fürthauer, M., Thisse, C., and Thisse, B. (1997) A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula. Development (Cambridge, England). 124(21):4253-4264

Babin, P.J., Thisse, C., Durliat, M., Andre, M., Akimenko, M.-A., and Thisse, B. (1997) Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 94(16):8622-8627

Halpern, M.E., Hatta, K., Amacher, S.L., Talbot, W.S., Yan, Y.-L., Thisse, B., Thisse, C., Postlethwait, J.H., and Kimmel, C.B. (1997) Genetic interactions in zebrafish midline development. Developmental Biology. 187(2):154-170

Taneja, R., Thisse, B., Rijli, F.M., Thisse, C., Bouillet, P., Dollé, P., and Chambon, P. (1996) The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos. Developmental Biology. 177(2):397-412

Halpern, M.E., Thisse, C., Ho, R.K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E.S., Postlethwait, J.H., and Kimmel, C.B. (1995) Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development (Cambridge, England). 121:4257-4264

Thisse, C., Thisse, B., and Postlethwait, J.H. (1995) Expression of snail2, a second member of the zebrafish Snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Developmental Biology. 172:86-99

Thisse, B., Thisse, C., and Weston, J.A. (1995) Novel FGF receptor (Z-FGFR4) is dynamically expressed in mesoderm and neurectoderm during early zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 203:377-391

Thisse, C., Thisse, B., Halpern, M.E., and Postlethwait, J.H. (1994) Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Developmental Biology. 164:420-429

Thisse, C., Thisse, B., Schilling, T.F., and Postlethwait, J.H. (1993) Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development (Cambridge, England). 119:1203-1215

NON-ZEBRAFISH PUBLICATIONS
Thisse, C. and Thisse, B. (1992). Dorsoventral development of the Drosophila embryo is controlled by a cascade of transcriptional regulators. Development Suppl. 173-181.

Thisse, C., Perrin-Schmitt, F., Stoetzel, C. and Thisse, B. (1991). Sequence specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell. 65 : 1191-1201.

Wolf, C., Thisse, C., Stoetzel, C., Thisse, B., Gerlinger, P. and Perrin-Schmitt, F. (1991). The M-twist gene of Mus is expressed in subset of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev. Biol. 143 : 363-373.

Thisse, B., Stoetzel, C., Gorostiza-Thisse, C. and Perrin-Schmitt, F. (1988). Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J. 7 : 2175 - 2183.

Thisse, B., Stoetzel, C., El Messal, and Perrin-Schmitt, F. (1987) gene of the maternal dorsal group control the specific expression of the zygotic gene twist in the presumptive mesodermal cells. Genes and Dev. 1 : 709 - 715.

Thisse, B., El Messal, M. and Perrin-Schmitt, F. (1987) The twist gene : Isolation of a Drosophila zygotic gene necessary for the establishment of dorso-ventral pattern. Nucl. Acids res. 15 : 3439 - 3453.