ZFIN ID: ZDB-PUB-010705-16
Pattern formation in the lateral line of zebrafish
Gompel, N., Cubedo, N., Thisse, C., Thisse, B., Dambly-Chaudiere, C., and Ghysen, A.
Date: 2001
Source: Mechanisms of Development   105(1-2): 69-77 (Journal)
Registered Authors: Cubedo, Nicolas, Ghysen, Alain, Gompel, Nicolas, Thisse, Bernard, Thisse, Christine
Keywords: vertebrates; zebrafish; lateral line; sensory system; peripheral nervous system; migratory primordium; hair cell; neuromasts; pattern formation
MeSH Terms:
  • Animals
  • Cell Lineage
  • Cell Movement
  • Cell Nucleus/metabolism
  • Dextrans/pharmacology
  • Fluorescein/pharmacology
  • Fluorescent Dyes/pharmacology
  • Gene Expression Regulation, Developmental*
  • Hair Cells, Auditory/metabolism
  • In Situ Hybridization
  • Microscopy, Video
  • Mitosis
  • Neurons/physiology*
  • Time Factors
  • Ultraviolet Rays
  • Zebrafish
PubMed: 11429283 Full text @ Mech. Dev.
The lateral line of fish and amphibians is a sensory system that comprises a number of individual sense organs, the neuromasts, arranged in a defined pattern on the surface of the body. A conspicuous part of the system is a line of organs that extends along each flank (and which gave the system its name). At the end of zebrafish embryogenesis, this line comprises 7-8 neuromasts regularly spaced between the ear and the tip of the tail. The neuromasts are deposited by a migrating primordium that originates from the otic region. Here, we follow the development of this pattern and show that heterogeneities within the migrating primordium prefigure neuromast formation.