PUBLICATION

Zebrafish: A Model System to Study Heritable Skin Diseases

Authors
Li, Q., Frank, M., Thisse, C.I., Thisse, B.V., and Uitto, J.
ID
ZDB-PUB-110103-29
Date
2011
Source
The Journal of investigative dermatology   131(3): 565-571 (Journal)
Registered Authors
Thisse, Bernard, Thisse, Christine
Keywords
none
MeSH Terms
  • Animals
  • Cell Membrane/metabolism
  • Cell Membrane/ultrastructure
  • Epidermis/cytology
  • Epidermis/metabolism
  • Epidermis/ultrastructure
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Mice
  • Models, Animal*
  • Skin Diseases/genetics*
  • Skin Diseases/metabolism
  • Zebrafish*
PubMed
21191402 Full text @ J. Invest. Dermatol.
Abstract
Heritable skin diseases represent a broad spectrum of clinical manifestations due to mutations in <500 different genes. A number of model systems have been developed to advance our understanding of the pathomechanisms of genodermatoses. Zebrafish (Danio rerio), a freshwater vertebrate, has a well-characterized genome, the expression of which can be easily manipulated. The larvae develop rapidly, with all major organs having developed by 5-6 days post-fertilization, including the skin, consisting of the epidermis comprising two cell layers and separated from the dermal collagenous matrix by a basement membrane. This perspective highlights the morphological and ultrastructural features of zebrafish skin, in the context of cutaneous gene expression. These observations suggest that zebrafish provide a useful model system to study the molecular aspects of skin development, as well as the pathogenesis and treatment of select heritable skin diseases.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes