ZFIN ID: ZDB-PERS-960805-549
Takeda, Hiroyuki
Email: htakeda@biol.s.u-tokyo.ac.jp
Affiliation: Group of Animal Morphogenesis During Development
Address: Department of Biological Sciences Graduate School of Science University of Tokyo Hongo 7-3-1, Bunkyo-ku Tokyo, 113-0033 Japan
Country: Japan
Phone: 81-3-5841-4431
Fax: 81-3-5841-4993


Ikeda, T., Inamori, K., Kawanishi, T., Takeda, H. (2022) Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation. Development, growth & differentiation. 64(3):163-177
Wu, X., Zhang, H., Zhang, B., Zhang, Y., Wang, Q., Shen, W., Wu, X., Li, L., Xia, W., Nakamura, R., Liu, B., Liu, F., Takeda, H., Meng, A., Xie, W. (2021) Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science advances. 7:eabl3858
Nakamura, R., Motai, Y., Kumagai, M., Wike, C.L., Nishiyama, H., Nakatani, Y., Durand, N.C., Kondo, K., Kondo, T., Tsukahara, T., Shimada, A., Cairns, B.R., Lieberman Aiden, E., Morishita, S., Takeda, H. (2021) CTCF looping is established during gastrulation in medaka embryos. Genome research. 31(6):968-980
Nakagama, Y., Takeda, N., Ogawa, S., Takeda, H., Furutani, Y., Nakanishi, T., Sato, T., Hirata, Y., Oka, A., Inuzuka, R. (2019) Noonan syndrome-associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish. Molecular genetics & genomic medicine. 8(3):e1107
Abe, K., Shimada, A., Tayama, S., Nishikawa, H., Kaneko, T., Tsuda, S., Karaiwa, A., Matsui, T., Ishitani, T., Takeda, H. (2019) Horizontal Boundary Cells, a Special Group of Somitic Cells, Play Crucial Roles in the Formation of Dorsoventral Compartments in Teleost Somite. Cell Reports. 27:928-939.e4
Yamaguchi, H., Oda, T., Kikkawa, M., Takeda, H. (2018) Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly. eLIFE. 7
Uchida, Y., Uesaka, M., Yamamoto, T., Takeda, H., Irie, N. (2018) Embryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos. EvoDevo. 9:7
Nakamura, R., Uno, A., Kumagai, M., Morishita, S., Takeda, H. (2017) Hypomethylated domain-enriched DNA motifs prepattern the accessible nucleosome organization in teleosts. Epigenetics & chromatin. 10:44
Yamamoto, T., Tsukahara, T., Ishiguro, T., Hagiwara, H., Taira, M., Takeda, H. (2015) The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts. BMC Developmental Biology. 15:9
Sato, A., and Takeda, H. (2013) Neuronal Subtypes Are Specified by the Level of neurod Expression in the Zebrafish Lateral Line. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(2):556-562
Khan, A., Nakamoto, A., Okamoto, S., Tai, M., Nakayama, Y., Kobayashi, K., Kawamura, A., Takeda, H., and Yamasu, K. (2012) Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. Mechanisms of Development. 129(9-12):219-235
Khan, A., Nakamoto, A., Tai, M., Saito, S., Nakayama, Y., Kawamura, A., Takeda, H., and Yamasu, K. (2012) Mesendoderm specification depends on the function of Pou2, the class V POU-type transcription factor, during zebrafish embryogenesis. Development, growth & differentiation. 54(7):686-701
Ishioka, A., Jindo, T., Kawanabe, T., Hatta, K., Parvin, M.S., Nikaido, M., Kuroyanagi, Y., Takeda, H., and Yamasu, K. (2011) Retinoic acid-dependent establishment of positional information in the hindbrain was conserved during vertebrate evolution. Developmental Biology. 350(1):154-168
Sato, A., Koshida, S., and Takeda, H. (2010) Single-cell analysis of somatotopic map formation in the zebrafish lateral line system. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2058-2065
Ishimatsu, K., Takamatsu, A., and Takeda, H. (2010) Emergence of traveling waves in the zebrafish segmentation clock. Development (Cambridge, England). 137(10):1595-1599
Parvin, M.S., Okuyama, N., Inoue, F., Islam, M.E., Kawakami, A., Takeda, H., and Yamasu, K. (2008) Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(5):1373-1388
Nagayoshi, S., Hayashi, E., Abe, G., Osato, N., Asakawa, K., Urasaki, A., Horikawa, K., Ikeo, K., Takeda, H., and Kawakami, K. (2008) Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. Development (Cambridge, England). 135(1):159-169
Ishimatsu, K., Horikawa, K., and Takeda, H. (2007) Coupling cellular oscillators: A mechanism that maintains synchrony against developmental noise in the segmentation clock. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(6):1416-1421
Yokoi, H., Shimada, A., Carl, M., Takashima, S., Kobayashi, D., Narita, T., Jindo, T., Kimura, T., Kitagawa, T., Kage, T., Sawada, A., Naruse, K., Asakawa, S., Shimizu, N., Mitani, H., Shima, A., Tsutsumi, M., Hori, H., Wittbrodt, J., Saga, Y., Ishikawa, Y., Araki, K., and Takeda, H. (2007) Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. Developmental Biology. 304(1):326-337
Sasaki, T., Shimizu, A., Ishikawa, S.K., Imai, S., Asakawa, S., Murayama, Y., Khorasani, M.Z., Mitani, H., Furutani-Seiki, M., Kondoh, H., Nanda, I., Schmid, M., Schartl, M., Nonaka, M., Takeda, H., Hori, H., Himmelbauer, H., Shima, A., and Shimizu, N. (2007) The DNA sequence of medaka chromosome LG22. Genomics. 89(1):124-133
Islam, M.E., Kikuta, H., Inoue, F., Kanai, M., Kawakami, A., Parvin, M.S., Takeda, H., and Yamasu, K. (2006) Three enhancer regions regulate gbx2 gene expression in the isthmic region during zebrafish development. Mechanisms of Development. 123(12):907-924
Sakaguchi, T., Kikuchi, Y., Kuroiwa, A., Takeda, H., and Stainier, D.Y. (2006) The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish. Development (Cambridge, England). 133(20):4063-4072
Horikawa, K., Ishimatsu, K., Yoshimoto, E., Kondo, S., and Takeda, H. (2006) Noise-resistant and synchronized oscillation of the segmentation clock. Nature. 441(7094):719-723
Kobayashi, D., Jindo, T., Naruse, K., and Takeda, H. (2006) Development of the endoderm and gut in medaka, Oryzias latipes. Development, growth & differentiation. 48(5):283-295
Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H., Kamachi, Y. (2006) Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(3):811-825
Shimoda, N., Yamakoshi, K., Miyake, A., and Takeda, H. (2005) Identification of a gene required for de novo DNA methylation of the zebrafish no tail gene. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(4):1509-1516
Murayama, E., Herbomel, P., Kawakami, A., Takeda, H., and Nagasawa H. (2005) Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mechanisms of Development. 122(6):791-803
Kawakami, A., Nojima, Y., Toyoda, A., Takahoko, M., Satoh, M., Tanaka, H., Wada, H., Masai, I., Terasaki, H., Sakaki, Y., Takeda, H., and Okamoto, H. (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Current biology : CB. 15(5):480-488
Kawahara, A., Che, Y.S., Hanaoka, R., Takeda, H., and Dawid, I.B. (2005) Zebrafish GADD45{beta} genes are involved in somite segmentation. Proceedings of the National Academy of Sciences of the United States of America. 102(2):361-366
Kawakami, A., Fukazawa, T., and Takeda, H. (2004) Early fin primordia of zebrafish larvae regenerate by a similar growth control mechanism with adult regeneration. Developmental Dynamics : an official publication of the American Association of Anatomists. 231(4):693-699
Kage, T., Takeda, H., Yasuda, T., Maruyama, K., Yamamoto, N., Yoshimoto, M., Araki, K., Inohaya, K., Okamoto, H., Yasumasu, S., Watanabe, K., Ito, H., and Ishikawa, Y. (2004) Morphogenesis and regionalization of the medaka embryonic brain. The Journal of comparative neurology. 476(3):219-239
Tanaka, K., Ohisa, S., Orihara, N., Sakaguchi, S., Horie, K., Hibiya, K., Konno, S., Miyake, A., Setiamarga, D., Takeda, H., Imai, Y., and Kudo, A. (2004) Characterization of mutations affecting embryonic hematopoiesis in the medaka, Oryzias latipes. Mechanisms of Development. 121(7-8):739-746
Sekimizu, K., Nishioka, N., Sasaki, H., Takeda, H., Karlstrom, R.O., and Kawakami, A. (2004) The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling. Development (Cambridge, England). 131(11):2521-2532
Takeuchi, M., Nakabayashi, J., Sakaguchi, T., Yamamoto, T.S., Takahashi, H., Takeda, H., and Ueno, N. (2003) The prickle-related gene in vertebrates is essential for gastrulation cell movements. Current biology : CB. 13(8):674-679
Takeda, H. (2002) Wave and somite segmentation: a view from zebrafish genetic analyses. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 47(15):2017-2023
Tonou-Fujimori, N., Takahashi, M., Onodera, H., Kikuta, H., Koshida, S., Takeda, H., and Yamasu, K. (2002) RETRACTED: Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerio. Gene expression patterns : GEP. 2(3-4):183-188
Holley, S.A. and Takeda, H. (2002) Catching a wave: the oscillator and wavefront that create the zebrafish somite. Seminars in cell & developmental biology. 13(6):481-486
Picker, A., Scholpp, S., Bohli, H., Takeda, H., and Brand, M. (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development (Cambridge, England). 129(13):3227-3239
Nikaido, M., Kawakami, A., Sawada, A., Furutani-Seiki, M., Takeda, H., and Araki, K. (2002) Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites. Nature Genetics. 31(2):195-199
Nomura-Kitabayashi, A., Takahashi, Y., Kitajima, S., Inoue, T., Takeda, H., and Saga, Y. (2002) Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. Development (Cambridge, England). 129(10):2473-2481
Koshida, S., Shinya, M., Nikaido, M., Ueno, N., Schulte-Merker, S., Kuroiwa, A., and Takeda, H. (2002) Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish. Developmental Biology. 244(1):9-20
Sakaguchi, T., Mizuno, T., and Takeda, H. (2002) Formation and patterning roles of the yolk syncytial layer. Results and problems in cell differentiation. 40:1-14
Sawada, A., Shinya, M., Jiang, Y.J., Kawakami, A., Kuroiwa, A., and Takeda, H. (2001) Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development (Cambridge, England). 128(23):4873-4880
Shinya, M., Koshida, S., Sawada, A., Kuroiwa, A., and Takeda, H. (2001) Fgf signalling through MAPK cascade is required for development of the subpallial telencephalon in zebrafish embryos. Development (Cambridge, England). 128(21):4153-4164
Sakaguchi, T., Kuroiwa, A., and Takeda, H. (2001) A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish. Mechanisms of Development. 107(1-2):25-38
Sakaguchi, T., Kuroiwa, A., and Takeda, H. (2001) Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis. Mechanisms of Development. 104(1-2):113-115
Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M., and Karlstrom, R.O. (2000) Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Mechanisms of Development. 96(2):165-174
Sawada, A., Fritz, A., Jiang, Y., Yamamoto, A., Yamasu, K., Kuroiwa, A., Saga, Y., and Takeda, H. (2000) Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites. Development (Cambridge, England). 127(8):1691-1702
Ananuma, K., Takeda, H., Amanuma, H., and Aoki, Y. (2000) Transgenic zebrafish for detecting mutations caused by compounds in aquatic environments. Nat. Biotechnol.. 18(1):62-65
Rodaway, A., Takeda, H., Koshida, S., Broadbent, J., Price, B., Smith, J.C., Patient, R., and Holder, N. (1999) Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-ß; family signals and discrimination of mesoderm and endoderm by FGF. Development (Cambridge, England). 126(14):3067-3078
Shinya, M., Furutani-Seiki, M., Kuroiwa, A., and Takeda, H. (1999) Mosaic analysis with oep mutant reveals a repressive interaction between floor-plate and non-floor-plate mutant cells in the zebrafish neural tube. Development, growth & differentiation. 41(2):135-142
Mizuno, T., Yamaha, E., Kuroiwa, A., and Takeda, H. (1999) Removal of vegetal yolk causes dorsal deficencies and impairs dorsal-inducing ability of the yolk cell in zebrafish. Mechanisms of Development. 81(1-2):51-63
Mizuno, T., Shinya, M., and Takeda, H. (1999) Cell and tissue transplantation in zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 127:15-28
Nikaido, M., Tada, M., Takeda, H., Kuroiwa, A., and Ueno, N. (1999) In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning. Development (Cambridge, England). 126:181-190
Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C.-H., Hibi, M., and Hirano, T. (1998) A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes & Development. 12:2345-2353
Kobayashi, M., Toyama, R., Takeda, H., Dawid, I.B., and Kawakami, K. (1998) Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (Cambridge, England). 125:2973-2982
Yamaha, E., Mizuno, T., Hasebe, Y., Takeda, H., Yamazaki, F. (1998) Dorsal specification in blastoderm at the blastula stage in the goldfish, Carassius auratus. Development, growth & differentiation. 40(3):267-275
Koshida, S., Shinya, M., Mizuno, T., Kuroiwa, A., and Takeda, H. (1998) Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast. Development (Cambridge, England). 125:1957-1966
Makita, R., Mizuno, T., Koshida, S., Kuroiwa, A., and Takeda, H. (1998) Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and no tail activity. Mechanisms of Development. 71:165-176
Mizuno, T., Yamaha, E., Wakahara, M., Kuroiwa, A., and Takeda, H. (1996) Mesoderm induction in zebrafish. Nature. 383(6596):131-132
Amanuma, K., Hamada, Y., and Takeda, H. (1995) Transgene expression and integration in the zebrafish, Danio rerio. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 40:2257-2264
Takeda, H. and Miyagawa, T. (1994) Commitment of cell fate in embryo of the zebrafish, Danio rerio. Fish Biol. J. Medaka. 6:33-45
Takeda, H., Matsuzaki, T., Oki, T., Miyagawa, T., and Amanuma, H. (1994) A novel POU domain gene, zebrafish pou2: expression and roles of two alternatively spliced twin products in early development. Genes & Development. 8:45-59
Matsuzaki, T., Amanuma, H., and Takeda, H. (1992) A POU-domain gene of zebrafish, ZFPOU1, specifically expressed in the developing neural tissues. Biochemical and Biophysical Research Communications. 187:1446-1453