|ZFIN ID: ZDB-PUB-010706-8|
Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis
Sakaguchi, T., Kuroiwa, A., and Takeda, H.
|Source:||Mechanisms of Development 104(1-2): 113-115 (Journal)|
|Registered Authors:||Sakaguchi, Takuya, Takeda, Hiroyuki|
|Keywords:||zebrafish; btg-b; Btg2; Hoxb9|
|PubMed:||11404086 Full text @ Mech. Dev.|
Sakaguchi, T., Kuroiwa, A., and Takeda, H. (2001) Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis. Mechanisms of Development. 104(1-2):113-115.
ABSTRACTBTG/tob family proteins are thought to be a potential tumor suppressor due to their anti-proliferative activity. We cloned zebrafish btg-b, a member of the BTG1/2 subfamily, using in situ hybridization screening. The tissue-specific expression of btg-b is first observed in the organizer region at the early gastrula stage. Later in development, the forebrain, the hindbrain, the polster and the paraxial mesoderm transiently express btg-b. Recently, mouse Btg1 and Btg2 have been shown to be a cofactor for Hoxb9. Double in situ hybridization with zebrafish btg-b and hoxb9a indicates that the expression domains of these two genes overlap in the posterior paraxial mesoderm.