PUBLICATION
Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis
- Authors
- Sakaguchi, T., Kuroiwa, A., and Takeda, H.
- ID
- ZDB-PUB-010706-8
- Date
- 2001
- Source
- Mechanisms of Development 104(1-2): 113-115 (Journal)
- Registered Authors
- Sakaguchi, Takuya, Takeda, Hiroyuki
- Keywords
- zebrafish; btg-b; Btg2; Hoxb9
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Blotting, Northern
- Brain/metabolism
- Carrier Proteins/biosynthesis*
- Carrier Proteins/genetics*
- Cell Cycle/genetics*
- Cloning, Molecular
- DNA, Complementary/metabolism
- Embryo, Nonmammalian/metabolism
- Gastrula/metabolism
- Gene Library
- In Situ Hybridization
- Mesoderm/metabolism
- Molecular Sequence Data
- Phylogeny
- Protein Structure, Tertiary
- Radiation Hybrid Mapping
- Time Factors
- Zebrafish/embryology*
- Zebrafish Proteins*
- PubMed
- 11404086 Full text @ Mech. Dev.
Citation
Sakaguchi, T., Kuroiwa, A., and Takeda, H. (2001) Expression of zebrafish btg-b, an anti-proliferative cofactor, during early embryogenesis. Mechanisms of Development. 104(1-2):113-115.
Abstract
BTG/tob family proteins are thought to be a potential tumor suppressor due to their anti-proliferative activity. We cloned zebrafish btg-b, a member of the BTG1/2 subfamily, using in situ hybridization screening. The tissue-specific expression of btg-b is first observed in the organizer region at the early gastrula stage. Later in development, the forebrain, the hindbrain, the polster and the paraxial mesoderm transiently express btg-b. Recently, mouse Btg1 and Btg2 have been shown to be a cofactor for Hoxb9. Double in situ hybridization with zebrafish btg-b and hoxb9a indicates that the expression domains of these two genes overlap in the posterior paraxial mesoderm.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping