ZFIN ID: ZDB-PUB-030117-1
Catching a wave: the oscillator and wavefront that create the zebrafish somite
Holley, S.A. and Takeda, H.
Date: 2002
Source: Seminars in cell & developmental biology   13(6): 481-486 (Review)
Registered Authors: Holley, Scott, Takeda, Hiroyuki
Keywords: her; delta; notch; fgf; fss/tbx24
MeSH Terms:
  • Animals
  • Biological Clocks
  • Embryonic and Fetal Development/genetics
  • Signal Transduction/genetics
  • Somites/cytology
  • Somites/physiology*
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed: 12468251 Full text @ Sem. Cell Dev. Biol.
Segmentation of the paraxial mesoderm is governed by an oscillator mechanism that creates a dynamic prepattern within the caudal presomitic mesoderm. The oscillator is comprised of genetic circuit involving the Notch signaling pathway and its target genes her1 and her7. The stabilization of the oscillating prepattern is antagonized by a gradient of Fgf signaling which is highest in the caudal presomitic mesoderm. Once the level of Fgf signaling declines in the rostral presomitic mesoderm, a wavefront mediated by the transcription factor fss/tbx24, stabilizes the prepattern and leads to the segmental expression of a number of genes which then establish segment polarity and initiate morphological somite formation.