Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
- Sawada, A., Shinya, M., Jiang, Y.J., Kawakami, A., Kuroiwa, A., and Takeda, H.
- Development (Cambridge, England) 128(23): 4873-4880 (Journal)
- Registered Authors
- Jiang, Yun-Jin, Sawada, Atsushi, Shinya, Minori, Takeda, Hiroyuki
- Fgf, somite, segmentation, tailbud, fused somites, after eight, her1, zebrafish, growth factor, receptor, presomitic mesoderm, mouse embryo, zebrafish, segmentation, expression, clock, notch, gene, somitogenesis
- MeSH Terms
- Body Patterning
- Cell Division
- Fibroblast Growth Factors/metabolism*
- Membrane Proteins/metabolism
- Mitogen-Activated Protein Kinases/metabolism*
- Models, Biological
- Receptors, Notch
- Signal Transduction
- 11731466 Full text @ Development
Sawada, A., Shinya, M., Jiang, Y.J., Kawakami, A., Kuroiwa, A., and Takeda, H. (2001) Fgf/MAPK signalling is a crucial positional cue in somite boundary formation. Development (Cambridge, England). 128(23):4873-4880.
The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes