ZFIN ID: ZDB-PUB-011214-9
Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
Sawada, A., Shinya, M., Jiang, Y.J., Kawakami, A., Kuroiwa, A., and Takeda, H.
Date: 2001
Source: Development (Cambridge, England)   128(23): 4873-4880 (Journal)
Registered Authors: Jiang, Yun-Jin, Sawada, Atsushi, Shinya, Minori, Takeda, Hiroyuki
Keywords: Fgf, somite, segmentation, tailbud, fused somites, after eight, her1, zebrafish, growth factor, receptor, presomitic mesoderm, mouse embryo, zebrafish, segmentation, expression, clock, notch, gene, somitogenesis
MeSH Terms:
  • Animals
  • Body Patterning
  • Cell Division
  • Fibroblast Growth Factors/metabolism*
  • Membrane Proteins/metabolism
  • Mitogen-Activated Protein Kinases/metabolism*
  • Models, Biological
  • Mutation
  • Receptors, Notch
  • Signal Transduction
  • Somites/cytology
  • Somites/metabolism*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism*
PubMed: 11731466
The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.