ZFIN Person: Luo, Lingfei

ZFIN ID: ZDB-PERS-130425-1

ZFIN ID: ZDB-PERS-130425-1

Luo, Lingfei

Email:	lluo@swu.edu.cn
URL:
Affiliation:	Lingfei Luo Lab
Address:	Laboratory of Molecular Developmental Biology School of Life Sciences, Southwest University 2 Tiansheng Road, Beibei 400715 Chongqing China
Country:	China
Phone:	+86-23-68367957
Fax:	+86-23-68367958
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

We are interested in the organogenesis and regeneration of digestive organs in particular liver and pancreas.

PUBLICATIONS

Wei, X., Tan, X., Chen, Q., Jiang, Y., Wu, G., Ma, X., Fu, J., Li, Y., Gang, K., Yang, Q., Ni, R., He, J., Luo, L. (2023) Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish. Cell Reports. 42:112660112660

Wu, C., Zhang, W., Luo, Y., Cheng, C., Wang, X., Jiang, Y., Li, S., Luo, L., Yang, Y. (2023) Zebrafish ppp1r21 mutant as a model for the study of primary biliary cholangitis. Journal of genetics and genomics = Yi chuan xue bao. 50(12):1004-1013

Xiao, C., Hou, J., Wang, F., Song, Y., Zheng, J., Luo, L., Wang, J., Ding, W., Zhu, X., Xiong, J.W. (2023) Endothelial Brg1 fine-tunes Notch signaling during zebrafish heart regeneration. NPJ Regenerative medicine. 8:2121

Yu, J., Ma, J., Li, Y., Zhou, Y., Luo, L., Yang, Y. (2023) Pax4-Ghrelin mediates the conversion of pancreatic ɛ-cells to β-cells after extreme β-cell loss in zebrafish. Development (Cambridge, England). 150(6):

He, J., Zhao, F., Chen, B., Cui, N., Li, Z., Qin, J., Luo, L., Zhao, C., Li, L. (2023) Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution. Science China. Life sciences. 66(6):1358-1378

Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178

Ma, J., Gu, Y., Liu, J., Song, J., Zhou, T., Jiang, M., Wen, Y., Guo, X., Zhou, Z., Sha, J., He, J., Hu, Z., Luo, L., Liu, M. (2022) Functional screening of congenital heart disease risk loci identifies 5 genes essential for heart development in zebrafish. Cellular and molecular life sciences : CMLS. 80:1919

Jiang, Z., Huang, L., Zhao, J., Li, Y., Ma, J., Ni, R., Yang, Q., Luo, L., Yang, Y., Chen, J. (2022) GoldenFish: a rapid and efficient system to customize constructs for zebrafish transgenesis. Journal of molecular cell biology. 14(12):

Yang, Y., Li, Y., Fu, J., Li, Y., Li, S., Ni, R., Yang, Q., Luo, L. (2022) Intestinal precursors avoid being misinduced to liver cells by activating Cdx-Wnt inhibition cascade. Proceedings of the National Academy of Sciences of the United States of America. 119:e2205110119

Zhao, F., He, J., Tang, J., Cui, N., Shi, Y., Li, Z., Liu, S., Wang, Y., Ma, M., Zhao, C., Luo, L., Li, L. (2022) Brain milieu induces early microglial maturation through the BAX-Notch axis. Nature communications. 13:6117

Jin, B., Xie, L., Zhan, D., Zhou, L., Feng, Z., He, J., Qin, J., Zhao, C., Luo, L., Li, L. (2022) Nrf2 dictates the neuronal survival and differentiation of embryonic zebrafish harboring compromised alanyl-tRNA synthetase. Development (Cambridge, England). 149(17)

Chen, J., He, J., Luo, L. (2022) The brain vascular damage-induced lymphatic ingrowth is directed by Cxcl12b/Cxcr4a. Development (Cambridge, England). 149(13)

Zhao, F., Lu, Y., Li, Z., He, J., Cui, N., Luo, L., Li, L. (2022) The CXCR4-CXCL12 axis promotes T-cell reconstitution via efficient hematopoietic immigration. Journal of genetics and genomics = Yi chuan xue bao. 49(12):1138-1150

Zhang, J., Zhou, Y., Li, S., Mo, D., Ma, J., Ni, R., Yang, Q., He, J., Luo, L. (2022) Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports. 39:110596

Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980

Zhang, C., Huang, R., Ma, X., Chen, J., Han, X., Li, L., Luo, L., Ruan, H., Huang, H. (2021) The Ribosome Biogenesis Factor Ltv1 Is Essential for Digestive Organ Development and Definitive Hematopoiesis in Zebrafish. Frontiers in cell and developmental biology. 9:704730

Chen, J., Li, X., Ni, R., Chen, Q., Yang, Q., He, J., Luo, L. (2021) Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell. 56(22):3115-3127.e6

Cai, P., Mao, X., Zhao, J., Nie, L., Jiang, Y., Yang, Q., Ni, R., He, J., Luo, L. (2021) Farnesoid X Receptor is Required for the Redifferentiation of Bi-potential Progenitor Cells during Biliary-Mediated Zebrafish Liver Regeneration. Hepatology (Baltimore, Md.). 74(6):3345-3361

Yang, Y., Wang, H., He, J., Shi, W., Jiang, Z., Gao, L., Jiang, Y., Ni, R., Yang, Q., Luo, L. (2021) A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 118(25):

Bao, W., Wang, X., Luo, L., Ni, R. (2021) The Lysosomal Storage Disorder Due to fig4a Mutation Causes Robust Liver Vacuolation in Zebrafish. Zebrafish. 18(3):175-183

Zhang, W., Chen, J., Ni, R., Yang, Q., Luo, L., He, J. (2021) Contributions of biliary epithelial cells to hepatocyte homeostasis and regeneration in zebrafish. iScience. 24:102142

Cao, Z., Meng, Y., Gong, F., Xu, Z., Liu, F., Fang, M., Zou, L., Liao, X., Wang, X., Luo, L., Li, X., Lu, H. (2021) Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration. Proceedings of the National Academy of Sciences of the United States of America. 118(2):

He, J., Mo, D., Chen, J., Luo, L. (2020) Combined whole-mount fluorescence in situ hybridization and antibody staining in zebrafish embryos and larvae. Nature Protocols. 15:3361-3379

Sun, X., Zhang, R., Chen, H., Du, X., Chen, S., Huang, J., Liu, M., Xu, M., Luo, F., Jin, M., Su, N., Qi, H., Yang, J., Tan, Q., Zhang, D., Ni, Z., Liang, S., Zhang, B., Chen, D., Zhang, X., Luo, L., Chen, L., Xie, Y. (2020) Fgfr3 mutation disrupts chondrogenesis and bone ossification in zebrafish model mimicking CATSHL syndrome partially via enhanced Wnt/β-catenin signaling. Theranostics. 10:7111-7130

Sun, X., Zhou, Y., Zhang, R., Wang, Z., Xu, M., Zhang, D., Huang, J., Luo, F., Li, F., Ni, Z., Zhou, S., Chen, H., Chen, S., Chen, L., Du, X., Chen, B., Huang, H., Liu, P., Yin, L., Qiu, J., Chen, D., Deng, C., Xie, Y., Luo, L., Chen, L. (2020) Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Nature communications. 11:479

Huang, S., Wang, Y., Luo, L., Li, X., Jin, X., Li, S., Yu, X., Yang, M., Guo, Z. (2019) BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development. Frontiers in Cellular Neuroscience. 13:523

Dong, G., Huang, Y., Ding, H., Luo, L., Zhang, Y., Huang, H., Ruan, H. (2019) Mypt1 regulates Bmp signaling to promote embryonic exocrine pancreas growth in zebrafish. Genesis (New York, N.Y. : 2000). 58(2):e23345

Huang, Y., Lu, Y., He, Y., Feng, Z., Zhan, Y., Huang, X., Liu, Q., Zhang, J., Li, H., Huang, H., Ma, M., Luo, L., Li, L. (2019) Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 & Irf4 in zebrafish. The Journal of biological chemistry. 294(44):16152-16163

Sun, X., Zhang, R., Liu, M., Chen, H., Chen, L., Luo, F., Zhang, D., Huang, J., Li, F., Ni, Z., Qi, H., Su, N., Jin, M., Yang, J., Tan, Q., Du, X., Chen, B., Huang, H., Chen, S., Yin, L., Xu, X., Deng, C., Luo, L., Xie, Y., Chen, L. (2019) Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage-hair hypoplasia via enhanced Wnt/β-catenin signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 34(11):2101-2116

He, J., Chen, J., Wei, X., Leng, H., Mu, H., Cai, P., Luo, L. (2019) mTORC1 Signaling is Required for the Dedifferentiation from Biliary Cell to Bi-potential Progenitor Cell in Zebrafish Liver Regeneration. Hepatology (Baltimore, Md.). 70(6):2092-2106

Chen, J., He, J., Ni, R., Yang, Q., Zhang, Y., Luo, L. (2019) Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish. Developmental Cell. 49(5):697-710.e5

Cao, Z., Mao, X., Luo, L. (2019) Germline Stem Cells Drive Ovary Regeneration in Zebrafish. Cell Reports. 26:1709-1717.e3

Yi, X., Yu, J., Ma, C., Dong, G., Shi, W., Li, H., Li, L., Luo, L., Sampath, K., Ruan, H., Huang, H. (2019) The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish. PLoS Genetics. 15:e1007408

Zhong, Y., Huang, W., Du, J., Wang, Z., He, J., Luo, L. (2018) Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and β cell development and regeneration in zebrafish. The Journal of biological chemistry. 294(3):932-940

Gao, C., Huang, W., Gao, Y., Jan Lo, L., Luo, L., Huang, H., Chen, J., Peng, J. (2018) Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1. Journal of molecular cell biology. 11(6):448-462

Wang, Z., Song, J., Luo, L., Ma, J. (2018) Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish. Biochemical and Biophysical Research Communications. 505(2):378-384

Zhan, Y., Huang, Y., Chen, J., Cao, Z., He, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2018) The caudal dorsal artery generates hematopoietic stem and progenitor cells via the endothelial-to-hematopoietic transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao.

Zou, Q., Gang, K., Yang, Q., Liu, X., Tang, X., Lu, H., He, J., Luo, L. (2018) The CCCH-type zinc finger transcription factor Zc3h8 represses NF-κB-mediated inflammation in digestive organs in zebrafish. The Journal of biological chemistry. 293(31):11971-11983

Yi, X., Yu, J., Ma, C., Li, L., Luo, L., Li, H., Ruan, H., Huang, H. (2018) Yap1/Taz are essential for the liver development in zebrafish. Biochemical and Biophysical Research Communications. 503(1):131-137

Ni, R., Luo, L. (2018) A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development. FEBS Open Bio. 8:722-731

Gao, C., Zhu, Z., Gao, Y., Lo, L.J., Chen, J., Luo, L., Peng, J. (2018) Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes. Journal of genetics and genomics = Yi chuan xue bao. 45:173-175

Cai, P., Mao, X., Zhao, J., Luo, L. (2018) Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochemical and Biophysical Research Communications. 497(2):776-782

He, J., Yang, Y., Zhang, J., Chen, J., Wei, X., He, J., Luo, L. (2017) Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 44(12):567-576

Tian, Y., Xu, J., Feng, S., He, S., Zhao, S., Zhu, L., Jin, W., Dai, Y., Luo, L., Qu, J.Y., Wen, Z. (2017) The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. The Journal of experimental medicine. 214(11):3347-3360

Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158

Wang, H., Luo, L., Yang, D. (2017) Loss of Gspt1l disturbs the patterning of the brain central arteries in zebrafish. Biochemical and Biophysical Research Communications. 486(1):156-162

Du, J., Yang, Q., Luo, L., Yang, D. (2017) C1qr and C1qrl redundantly regulate angiogenesis in zebrafish through controlling endothelial Cdh5. Biochemical and Biophysical Research Communications. 483(1):482-487

Hou, Y., Sheng, Z., Mao, X., Li, C., Chen, J., Zhang, J., Huang, H., Ruan, H., Luo, L., Li, L. (2016) Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissue. Scientific Reports. 6:36853

Chen, J., He, J., Li, L., Yang, D., Luo, L. (2016) Cyp2aa9 regulates haematopoietic stem cell development in zebrafish. Scientific Reports. 6:26608

Liu, C., Wu, C., Yang, Q., Gao, J., Li, L., Yang, D., Luo, L. (2016) Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction. Immunity. 44(5):1162-76

Cao, Z., Wang, H., Mao, X., Luo, L. (2016) Noncanonical function of Threonyl-tRNA synthetase regulates Vascular Development in Zebrafish. Biochemical and Biophysical Research Communications. 473(1):67-72

Jia, X.E., Ma, K., Xu, T., Gao, L., Wu, S., Fu, C., Zhang, W., Wang, Z., Liu, K., Dong, M., Jing, C., Ren, C., Dong, Z., Chen, Y., Jin, Y., Huang, Q., Chang, X., Deng, M., Li, L., Luo, L., Zhu, J., Dang, Y., Chang, H.C., Zon, L.I., Zhou, Y., Chen, S., Pan, W. (2015) Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Research. 25(8):946-62

Jiang, F., Chen, J., Ma, X., Huang, C., Zhu, S., Wang, F., Li, L., Luo, L., Ruan, H., Huang, H. (2015) Analysis of mutants from a genetic screening reveals the control of intestine and liver development by many common genes in zebrafish. Biochemical and Biophysical Research Communications. 460(3):838-44

Shi, W., Fang, Z., Li, L., Luo, L. (2015) Using zebrafish as the model organism to understand organ regeneration. Science China. Life sciences. 58:343-51

Shi, Y., Zhang, Y., Zhao, F., Ruan, H., Huang, H., Luo, L., Li, L. (2014) Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish. Scientific Reports. 4:5602

He, J., Lu, H., Zou, Q., and Luo, L. (2014) Regeneration of Liver After Extreme Hepatocyte Loss Occurs Mainly via Biliary Transdifferentiation in Zebrafish. Gastroenterology. 146(3):789-800.e8

Li, L., and Luo, L.F. (2013) Zebrafish as the model system to study organogenesis and regeneration. Yi chuan = Hereditas. 35(4):421-432

Lu, H., Ma, J., Yang, Y., Shi, W., and Luo, L. (2013) EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development. Developmental Cell. 24(5):543-553

Huang, S., Ma, J., Liu, X., Zhang, Y., and Luo, L. (2011) Retinoic acid signaling sequentially controls visceral and heart laterality in Zebrafish. The Journal of biological chemistry. 286(32):28533-43

Huang, S., Ma, J., Liu, X., Zhang, Y., and Luo, L. (2011) Geminin is required for left-right patterning through regulating Kupffer's vesicle formation and ciliogenesis in zebrafish. Biochemical and Biophysical Research Communications. 410(2):164-9

Liu, X., Huang, S., Ma, J., Li, C., Zhang, Y., and Luo, L. (2009) NF-kappaB and Snail1a coordinate the cell cycle with gastrulation. The Journal of cell biology. 184(6):805-815

NON-ZEBRAFISH PUBLICATIONS
Huiqiang Lu, Jun Ma, Yun Yang, Wenchao Shi, Lingfei Luo*. (2013). EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Dev. Cell 24(5), 543-553.

Zhuan Li, Yu Lan, Wenyan He, Dongbo Chen, Jun Wang, Fan Zhou, Yu Wang, Huayan Sun, Xianda Chen, Chunhong Xu, Sha Li, Yakun Pang, Guangzhou Zhang, Liping Yang, Lingling Zhu, Ming Fan, Aijia Shang, Zhenyu Ju, Lingfei Luo, Yuqiang Ding, Wei Guo, Weiping Yuan, Xiao Yang, Bing Liu*. (2012). Mouse embryonic head as a site for hematopoietic stem cell development. Cell Stem Cell 11(5), 663-675.

Sizhou Huang, Jun Ma, Xiaolin Liu, Yaoguang Zhang, Lingfei Luo*. (2011). Retinoic acid signaling sequentially controls visceral and heart laterality in zebrafish. J. Biol. Chem. 286(32), 28533-28543.

Sizhou Huang, Jun Ma, Xiaolin Liu, Yaoguang Zhang, Lingfei Luo*. (2011). Geminin is required for left-right patterning through regulating Kupffer’s vesicle formation and ciliogenesis in zebrafish. Biochem. Biophys. Res. Commun. 410(2), 164-169.

Xiaolin Liu, Sizhou Huang, Jun Ma, Chun Li, Yaoguang Zhang, Lingfei Luo*. (2009). NF-κB and Snail1a coordinate the cell cycle with gastrulation. J. Cell Biol. 184(6), 805-815.

Lingfei Luo*, Yvonne Uerlings, Naisana S. Asli, Nicole Happel, Hendrik Knoetgen, Michael Kessel. (2007). Regulation of geminin functions by cell cycle dependent nuclear-cytoplasmic shuttling. Mol. Cell. Biol. 27(13), 4737-4744.

Mara Pitulescu, Michael Kessel, Lingfei Luo*. (2005). The regulation of embryonic patterning and DNA replication by geminin. Cell. Mol. Life Sci. 62(13), 1425-1433.

Lingfei Luo, Michael Kessel*. (2004). Geminin coordinates cell cycle and developmental control. Cell Cycle 3(6), 711-714.

Lingfei Luo, Xiaoping Yang, Yoshihiro Takihara, Hendrik Knoetgen, Michael Kessel*. (2004). The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 427(6976), 749-753.