PUBLICATION

Zebrafish as the model system to study organogenesis and regeneration

Authors
Li, L., and Luo, L.F.
ID
ZDB-PUB-130610-21
Date
2013
Source
Yi chuan = Hereditas   35(4): 421-432 (Journal)
Registered Authors
Li, Li, Luo, Lingfei
Keywords
none
MeSH Terms
  • Animals
  • Humans
  • Models, Animal*
  • Organ Specificity
  • Organogenesis*
  • Regeneration*
  • Zebrafish/embryology*
  • Zebrafish/physiology*
PubMed
23659932 Full text @ Yi Chuan
Abstract

Zebrafish (Danio rerio) is becoming more and more popular as a model organism to study vertebrate organogenesis and regeneration, taking the advantage of its extra-uterine development, transparency, strong regeneration ability and suitability for the large scale genetic screen. In the past decades, a series of useful methods have been established in zebrafish, which allows studies of important questions in developmental biology including cell fate determination, differentiation, morphogenesis, and regeneration after tissue/organ injury. Recently, using large scale mutagenesis screen and improved live imaging techniques, many questions that had not been well understood in mice have been successfully investigated in zebrafish. Therefore, we are confident that the zebrafish model system will further help decipher the cellular and molecular mechanisms of organogenesis and regeneration in the future, providing valuable references for the treatment of related clinical diseases. This review just summarized the progress in the studies of the important organs development using zebrafish, such as central nervous system(CNS), liver and pancreas, blood and vessel, recently. Meanwhile, the updated informations about the regeneration of tail fin, heart, liver, retina and so on in zebrafish were also included in this paper.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes
Article is in Chinese.