PUBLICATION

Using zebrafish as the model organism to understand organ regeneration

Authors
Shi, W., Fang, Z., Li, L., Luo, L.
ID
ZDB-PUB-150412-6
Date
2015
Source
Science China. Life sciences   58: 343-51 (Review)
Registered Authors
Li, Li, Luo, Lingfei, Shi, Wenchao
Keywords
none
MeSH Terms
  • Animals
  • Models, Animal*
  • Regeneration*
  • Zebrafish*
PubMed
25862658 Full text @ Sci. China Ser. C-Life Sci.
Abstract
The limited regenerative capacity of several organs, such as central nervous system (CNS), heart and limb in mammals makes related major diseases quite difficult to recover. Therefore, dissection of the cellular and molecular mechanisms underlying organ regeneration is of great scientific and clinical interests. Tremendous progression has already been made after extensive investigations using several model organisms for decades. Unfortunately, distance to the final achievement of the goal still remains. Recently, zebrafish became a popular model organism for the deep understanding of regeneration based on its powerful regenerative capacity, in particular the organs that are limitedly regenerated in mammals. Additionally, zebrafish are endowed with other advantages good for the study of organ regeneration. This review summarizes the recent progress in the study of zebrafish organ regeneration, in particular regeneration of fin, heart, CNS, and liver as the representatives. We also discuss reasons of the reduced regenerative capacity in higher vertebrate, the roles of inflammation during regeneration, and the difference between organogenesis and regeneration.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes