FIGURE

Fig. 3

ID
ZDB-FIG-210218-17
Publication
Zhao et al., 2021 - Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish
Other Figures
All Figure Page
Back to All Figure Page
Fig. 3

Depletion of <italic>Δ113p53</italic> results in an elevated level of intracellular H<sub>2</sub>O<sub>2</sub> in zebrafish telencephalons.

AC Relative mRNA expression of aldh4a1, gpx1a, sesn1, sod2 at 3- (A), 6- (B), and 10-months old (C) in the Δ113p53+/+ or Δ113p53M/M telencephalons. The total RNA was extracted from a pool of at least six telencephalons in each group. The average gene expression was normalized against β-actin and expressed as fold change. D The relative concentration of H2O2 in the Δ113p53+/+ and Δ113p53M/M telencephalons at 3-, 6-, and 13-months old as indicated. Each group was measured based on a pool of at least four telencephalons. Statistical analysis was performed on relevant data using the Student’s two-tailed t test. *P < 0.05, **P < 0.01, ***P < 0.001.

Expression Data
Genes:
Fish:
Anatomical Term:
Stage: Adult

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Adult

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.