Gene
sod2
- ID
- ZDB-GENE-030131-7742
- Name
- superoxide dismutase 2, mitochondrial
- Symbol
- sod2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have manganese ion binding activity and superoxide dismutase activity. Involved in several processes, including neutrophil homeostasis; removal of superoxide radicals; and response to methylmercury. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); lipid storage disease (multiple); optic nerve disease (multiple); and rheumatic disease (multiple). Is expressed in several structures, including blood island; hematopoietic cell; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human SOD2 (superoxide dismutase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb463 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Peterman et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Microvascular complications of diabetes 6} | 612634 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR019833 | Manganese/iron superoxide dismutase, binding site |
| Domain | IPR019831 | Manganese/iron superoxide dismutase, N-terminal |
| Domain | IPR019832 | Manganese/iron superoxide dismutase, C-terminal |
| Family | IPR001189 | Manganese/iron superoxide dismutase |
| Homologous_superfamily | IPR036314 | Manganese/iron superoxide dismutase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036324 | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Manganese/iron superoxide dismutase | Manganese/iron superoxide dismutase, binding site | Manganese/iron superoxide dismutase, C-terminal | Manganese/iron superoxide dismutase, C-terminal domain superfamily | Manganese/iron superoxide dismutase, N-terminal | Manganese/iron superoxide dismutase, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P980
|
224 | ||||||
|
UniProtKB:Q2TV65
|
224 |
Interactions and Pathways
No data available
Plasmids
No data available