ZFIN ID: ZDB-GENE-040718-408
Gene Name: sestrin 1
Gene Symbol: sesn1    Nomenclature History

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Previous Names: si:ch211-51a19.4, WITHDRAWN: zgc:103669, zgc:103669 (1), zgc:91970

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in determination of left/right symmetry. Predicted to colocalize with the GATOR2 complex; TORC2 complex; and cytoplasm. Is expressed in several structures, including anterior axial hypoblast; central nervous system; mesoderm; presumptive paraxial mesoderm; and pronephros. Orthologous to human SESN1 (sestrin 1).
Genome Resources: Alliance (1),  Gene:436933 (1),  Ensembl(GRCz11):ENSDARG00000020693 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013861Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14435 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23741 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29391 Point Mutation Unknown Premature Stop ENU
    sa44943 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-sesn1
    2
    CRISPR2-sesn1
    2
    MO1-sesn1 N/A 1
    MO2-sesn1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sesn1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sesn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component nucleus (more)
    Molecular Function leucine binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR006730 Sestrin
    Homologous_superfamily IPR029032 AhpD-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sesn1-201 (1)    Ensembl 3992
    sesn1-202 (1)    Ensembl 920
    sesn1-203 (1)    Ensembl 4024
    sesn1-204 (1)    Ensembl 1897
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sesn1 No data available
    MARKER RELATIONSHIPS
    sesn1 Contained in: [BAC] CH211-51A19 (1), DKEY-222O17 (1) (order this)
    sesn1 Encodes: [cDNA] MGC:91970 (1), MGC:103669
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002660 (1) 3145 nt
    Genomic GenBank:BX510959 (1) 179085 nt
    Select Tool
    Polypeptide UniProtKB:U3JAG5 (1) 547 aa
    Sequence Information (all 26)
    ORTHOLOGY for sesn1 ( Chr: 20 )
    CITATIONS (30)