ZFIN ID: ZDB-GENE-040426-1179
Gene Name: aldehyde dehydrogenase 4 family, member A1
Gene Symbol: aldh4a1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:63592

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in oxidation-reduction process and proline catabolic process to glutamate. Predicted to localize to mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1).
Genome Resources: Alliance (1),  Gene:394133 (1),  Ensembl(GRCz11):ENSDARG00000038207 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-aldh4a1 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH aldh4a1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hyperprolinemia type 2 Alliance Hyperprolinemia, type II 239510
DISEASE ASSOCIATED WITH aldh4a1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component mitochondrial matrix (more)
Molecular Function 1-pyrroline-5-carboxylate dehydrogenase activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA aldh4a1-001 (1) 4297
aldh4a1-201 (1)    Ensembl 805
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM aldh4a1 No data available
MARKER RELATIONSHIPS
aldh4a1 Contained in: [Fosmid] CH1073-347B24 (1), ZFOS-1132D4 (1)
aldh4a1 Encodes: [cDNA] MGC:63592 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201158 (1) 1985 nt
Genomic GenBank:CU633737 (1) 27522 nt
Select Tool
Polypeptide UniProtKB:A0A140LG76 (1) 556 aa
Sequence Information (all 16)
ORTHOLOGY for aldh4a1 ( Chr: 11 )
CITATIONS (27)