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General Information
ZIRC
ZFIN ID: ZDB-FIG-180223-19
Zhang et al., 2017 - m6A modulates haematopoietic stem and progenitor cell specification.. Nature   549(7671):273-276 Full text @ Nature
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Prim-5 to Day 4
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Prim-5 to Day 4

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP ioz1Tg; s896Tg standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell IFL
Day 4 thymus lymphocyte IFL
ioz1Tg; s896Tg + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell IFL
Day 4 thymus lymphocyte IFL
s896Tg; zf169Tg standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell IFL
s896Tg; zf169Tg + MO1-mettl3 standard conditions Prim-25 hematopoietic multipotent progenitor cell IFL
gata1a TU standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
TU + MO1-mettl3 standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
mCherry ioz1Tg; s896Tg standard conditions Prim-25 ventral wall of dorsal aorta IFL
ioz1Tg; s896Tg + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta IFL
s896Tg; zf169Tg standard conditions Prim-25 ventral wall of dorsal aorta IFL
s896Tg; zf169Tg + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta IFL
myb TU standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
TU + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
rag1 TU standard conditions Prim-5 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
TU + MO1-mettl3 standard conditions Prim-5 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
spi1b TU standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
TU + MO1-mettl3 standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
TU + MO1-mettl3 standard conditions Prim-5 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell rag1 expression decreased amount, abnormal
TU + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell myb expression decreased amount, abnormal
TU + MO1-mettl3 standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell gata1a expression decreased amount, abnormal
TU + MO1-mettl3 standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell spi1b expression decreased amount, abnormal
TU + MO1-mettl3 standard conditions Day 4 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell rag1 expression decreased amount, abnormal
ioz1Tg; s896Tg + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta lacks parts or has fewer parts of type hematopoietic multipotent progenitor cell, abnormal
Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell EGFP expression decreased amount, abnormal
Day 4 thymus has fewer parts of type T cell, abnormal
Day 4 thymus lymphocyte EGFP expression decreased amount, abnormal
s896Tg; zf169Tg + MO1-mettl3 standard conditions Prim-25 ventral wall of dorsal aorta lacks parts or has fewer parts of type hematopoietic multipotent progenitor cell, abnormal
Full text @ Nature