ZFIN ID: ZDB-GENE-991110-14
Gene Name: v-myb avian myeloblastosis viral oncogene homolog
Gene Symbol: myb    Nomenclature History

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Previous Names: c-myb, cmyb

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including definitive hemopoiesis; hematopoietic stem cell migration; and regulation of neutrophil differentiation. Localizes to the chromatin. Is expressed in several structures, including head; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human MYB (MYB proto-oncogene, transcription factor).
Genome Resources: Alliance (1),  Gene:30519 (1),  Ensembl(GRCz11):ENSDARG00000053666 (1)
GENE EXPRESSION
All Expression Data: 374 figures from 179 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2005 [eu660]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hkz3 Point Mutation Intron 8 Splicing Variant ENU
sa32456 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32457 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t25127 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myb N/A 1
    MO2-myb N/A 5
    MO3-myb N/A 1
    DISEASE ASSOCIATED WITH myb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {T-cell acute lymphoblastic leukemia}
    DISEASE ASSOCIATED WITH myb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component chromatin (more)
    Molecular Function DNA-binding transcription factor activity, RNA polymerase II-specific (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001005 SANT/Myb domain
    Domain IPR012642 Transcription regulator Wos2-domain
    Domain IPR015395 C-myb, C-terminal
    Domain IPR017930 Myb domain
    Family IPR015495 Myb-like transcription factor
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myb-201 (1)    Ensembl 2085
    myb-202 (1)    Ensembl 3317
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cmyb monoclonal IgG2a Mouse WB Bio-Rad AbD Serotec
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:MYC-myb) hsp70l myb Danio rerio 1 7
    TgBAC(myb:GFP) myb GFP Danio rerio 1 4
    TgPAC(myb:2xmyb-EGFP) myb EGFPmyb Danio rerio 1 89
    MARKER RELATIONSHIPS
    myb Contained in: [BAC] DKEY-161P7 (1) (order this), DKEY-172L11 (1) (order this)
    myb Encodes: [EST] eu660 (1)
    [cDNA] MGC:65745 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131266 (1) 2085 nt
    Genomic GenBank:BX927365 (1) 229608 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q8E3 (1) 641 aa
    Sequence Information (all 20)
    ORTHOLOGY for myb ( Chr: 23 )
    CITATIONS (315)