ZFIN ID: ZDB-GENE-990415-234
Gene Name: recombination activating 1
Gene Symbol: rag1    Nomenclature History

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Previous Names: etID309719.25 (1), recombinase

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits magnesium ion binding activity and sequence-specific DNA binding activity. Contributes to double-stranded DNA endodeoxyribonuclease activity. Involved in V(D)J recombination and protein-DNA complex assembly. Localizes to DNA recombinase complex and endodeoxyribonuclease complex. Is expressed in gonad; hematopoietic cell; hypophysis; immune system; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in Omenn syndrome; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Orthologous to human RAG1 (recombination activating 1).
Genome Resources: Alliance (1),  Gene:30663 (1),  Ensembl(GRCz11):ENSDARG00000052122 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu1999 Point Mutation Unknown Premature Stop ENU
sa32518 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t26683 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zf2024 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rag1 N/A 1
    MO2-rag1 N/A 1
    MO3-rag1 N/A 2
    DISEASE ASSOCIATED WITH rag1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Omenn syndrome Alliance Omenn syndrome 603554
    severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive Alliance Severe combined immunodeficiency, B cell-negative 601457
    Alpha/beta T-cell lymphopenia with gamma/delta T-cell expansion, severe cytomegalovirus infection, and autoimmunity 609889
    Combined cellular and humoral immune defects with granulomas 233650
    DISEASE ASSOCIATED WITH rag1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein-DNA complex assembly (more)
    Cellular Component DNA recombinase complex (more)
    Molecular Function magnesium ion binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rag1-201 (1)    Ensembl 4485
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-rag1 polyclonal Rabbit IHC 1
    CONSTRUCTS WITH SEQUENCES FROM rag1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(rag1:GFP) rag1 GFP Danio rerio 1 8
    MARKER RELATIONSHIPS
    rag1 Contained in: [BAC] CH211-256A21 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131389 (1) 3174 nt
    Genomic GenBank:AL935203 (1) 163572 nt
    Select Tool
    Polypeptide UniProtKB:F1QD74 (1) 1057 aa
    Sequence Information (all 23)
    ORTHOLOGY for rag1 ( Chr: 25 )
    CITATIONS (287)