Gene

gata1a

ID
ZDB-GENE-980526-268
Name
GATA binding protein 1a
Symbol
gata1a Nomenclature History
Previous Names
  • gata1
  • gta1 (1)
  • zg1
  • etID309774.11 (1)
  • sb:eu551
  • vlad tepes
  • vlt
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hemopoiesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in Down syndrome; X-linked recessive disease (multiple); beta thalassemia; bone marrow cancer (multiple); and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
434 figures from 302 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
24 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gata1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Down syndrome Alliance Leukemia, megakaryoblastic, with or without Down syndrome, somatic 190685
thrombocytopenia Alliance Thrombocytopenia, X-linked, with or without dyserythropoietic anemia 300367
X-linked dyserythropoietic anemia Alliance Anemia, X-linked, with/without neutropenia and/or platelet abnormalities 300835
X-linked thrombocytopenia with beta-thalassemia Alliance Thrombocytopenia with beta-thalassemia, X-linked 314050
Associated With gata1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Family IPR016374 Transcription factor, GATA-2/3
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Domain Details Per Protein
Protein Length Transcription factor GATA Transcription factor, GATA-2/3 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:Q05AJ3 418
UniProtKB:Q90410 418
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations