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ZIRC
ZFIN ID: ZDB-GENE-980526-268
Gene Name: GATA binding protein 1a
Gene Symbol: gata1a    Nomenclature History

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Previous Names: gata1, gta1 (1), zg1, etID309774.11 (1), sb:eu551, vlad tepes, vlt

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hemopoiesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in Down syndrome; beta thalassemia; myelodysplastic syndrome; myelofibrosis; and transient myeloproliferative syndrome. Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Orthologous to human GATA1 (GATA binding protein 1).
Genome Resources: Alliance (1),  Gene:30481 (1),  Ensembl(GRCz11):ENSDARG00000013477 (1)
GENE EXPRESSION
All Expression Data: 406 figures from 288 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2005 [eu551]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cig8Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
hg2 Point Mutation Unknown Missense ENU
hg3 Point Mutation Unknown Missense ENU
m651 Point Mutation Unknown Premature Stop ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1048 Point Mutation Unknown Splice Site ENU
    sa18633 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gata1a
    1
    CRISPR2-gata1a
    2
    CRISPR3-gata1a 1
    MO1-gata1a N/A 37
    MO2-gata1a N/A 7
    MO3-gata1a N/A 1
    MO4-gata1a N/A 1
    DISEASE ASSOCIATED WITH gata1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Down syndrome Alliance Leukemia, megakaryoblastic, with or without Down syndrome, somatic 190685
    thrombocytopenia Alliance Thrombocytopenia, X-linked, with or without dyserythropoietic anemia 300367
    Anemia, X-linked, with/without neutropenia and/or platelet abnormalities 300835
    Thrombocytopenia with beta-thalassemia, X-linked 314050
    DISEASE ASSOCIATED WITH gata1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myeloid cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 26)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gata1a-201 (1)    Ensembl 1657
    ncRNA gata1a-002 (1)    Ensembl 730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gata1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-8.1gata1:gata1-EGFP) gata1a EGFP Danio rerio 1 10
    Tg(-8.1gata1a:mRFP) gata1a mRFP Danio rerio 1 8
    Tg(gata1a:deltaBR-GFP) gata1a GFP Danio rerio 1 3
    Tg(gata1a:DsRed) gata1a DsRed Danio rerio 1 297
    Tg(gata1a:EGFP) gata1a EGFP Danio rerio 5 11
    Tg(gata1a:EGFP-2xPT) gata1a EGFP Danio rerio 9 3
    Tg(gata1a:EGFP-UTR-klfd) gata1a EGFPklf1UTR Danio rerio 10 2
    Tg(gata1a:GFP) gata1a GFP Danio rerio 2 57
    Tg(gata1a:mir30e-2-shRNAEGFP-actb1-DsRed) gata1a actb1DsRedEGFPmir30e-2 Danio rerio 6 2
    Tg(gata1a:RFP) gata1a RFP Danio rerio 1 1
    Tg(gata1a:urod-GFP) gata1a GFPurod Danio rerio 1 3
    Tg(myl7:GFP,U6:CRISPR1-urod,gata1a:zCas9) gata1amyl7 CRISPR1-urodGFPzCas9 Danio rerio 1 1
    Tg(myl7:GFP,U6:GFP,gata1a:zCas9) gata1amyl7 GFPzCas9 Danio rerio 1 1
    Tg2(gata1a:DsRed) gata1a DsRed Danio rerio 1 2
    Tg2(gata1a:GFP) gata1a GFP Danio rerio 1 2
    tg3(gata1a:dsred) gata1a DsRed Danio rerio 1 1
    MARKER RELATIONSHIPS
    gata1a Contained in: [BAC] DKEYP-97E7 (1)
    gata1a Encodes: [EST] eu551 (1)
    [cDNA] MGC:153883 (1) (order this), MGC:191963 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131234 (1) 1694 bp
    Genomic GenBank:CR932000 (1) 77992 bp
    Select Tool
    Polypeptide UniProtKB:Q05AJ3 (1) 418 aa
    Sequence Clusters UniGene:355 (1)
    Sequence Information (all 19)
    ORTHOLOGY for gata1a ( Chr: 11 )
    CITATIONS (550)