Gene

gata1a

ID
ZDB-GENE-980526-268
Name
GATA binding protein 1a
Symbol
gata1a Nomenclature History
Previous Names
  • gata1
  • gta1 (1)
  • zg1
  • etID309774.11 (1)
  • sb:eu551
  • vlad tepes
  • vlt
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including hemopoiesis; regulation of gene expression; and regulation of myeloid cell differentiation. Predicted to localize to nuclear chromatin. Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in Down syndrome; X-linked thrombocytopenia with beta-thalassemia; beta thalassemia; and bone marrow cancer (multiple). Orthologous to human GATA1 (GATA binding protein 1).
Genome Resources
Note
None
Expression
All Expression Data
433 figures from 301 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
24 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gata1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Down syndrome Alliance Leukemia, megakaryoblastic, with or without Down syndrome, somatic 190685
thrombocytopenia Alliance Thrombocytopenia, X-linked, with or without dyserythropoietic anemia 300367
X-linked thrombocytopenia with beta-thalassemia Alliance Thrombocytopenia with beta-thalassemia, X-linked 314050
Anemia, X-linked, with/without neutropenia and/or platelet abnormalities 300835
Associated With gata1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Family IPR016374 Transcription factor, GATA-2/3
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Domain Details Per Protein
Protein Length Transcription factor GATA Transcription factor, GATA-2/3 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:Q90410 418
UniProtKB:Q05AJ3 418
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations