Gene

spi1b

ID
ZDB-GENE-980526-164
Name
Spi-1 proto-oncogene b
Symbol
spi1b Nomenclature History
Previous Names
  • pu.1
  • pu1
  • spi1 (1)
  • cb1086 (1)
  • si:by184l24.2
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in myeloid cell differentiation; negative regulation of myeloid cell differentiation; and positive regulation of gene expression. Predicted to localize to nucleus. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; trunk; and yolk. Orthologous to human SPI1 (Spi-1 proto-oncogene).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
230 figures from 153 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
39 figures from 29 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With spi1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
agammaglobulinemia 10 Alliance Agammaglobulinemia 10, autosomal dominant 619707
Associated With spi1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000418 Ets domain
Family IPR046328 ETS family
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Ets domain ETS family Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1R668 266
UniProtKB:Q78AM8 296
UniProtKB:A0A8M2BG46 297
UniProtKB:Q8AW41 265
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-spi1 Rabbit
  • IHC
2
Ab1-spi1 polyclonal IgG Rabbit
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations