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General Information
ZIRC
ZFIN ID: ZDB-FIG-180307-3
Zhang et al., 2017 - m6A modulates haematopoietic stem and progenitor cell specification.. Nature   549(7671):273-276 Full text @ Nature
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Condition:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Prim-5 to Prim-25
PHENOTYPE:
Fish:
Condition:
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Prim-25

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP ioz1Tg; s896Tg standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell IFL
ioz1Tg; s896Tg + MO1-ythdf2 standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell IFL
mCherry ioz1Tg; s896Tg standard conditions Prim-25 ventral wall of dorsal aorta IFL
ioz1Tg; s896Tg + MO1-ythdf2 standard conditions Prim-25 ventral wall of dorsal aorta IFL
notch1a TU chemical treatment: actinomycin D Prim-5 to Prim-25 whole organism RTPCR
TU + MO1-mettl3 chemical treatment: actinomycin D Prim-5 to Prim-25 whole organism RTPCR
TU + MO1-ythdf2 chemical treatment: actinomycin D Prim-5 to Prim-25 whole organism RTPCR
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
TU chemical treatment: actinomycin D Prim-5 - Prim-25 whole organism notch1a expression decreased amount, abnormal
TU + MO1-mettl3 chemical treatment: actinomycin D Prim-5 - Prim-25 whole organism notch1a expression increased amount, abnormal
TU + MO1-ythdf2 chemical treatment: actinomycin D Prim-5 - Prim-25 whole organism notch1a expression increased amount, abnormal
ioz1Tg; s896Tg + MO1-ythdf2 standard conditions Prim-25 ventral wall of dorsal aorta hematopoietic multipotent progenitor cell EGFP expression decreased amount, abnormal
Full text @ Nature