FIGURE

Fig. 10

ID

ZDB-FIG-170227-9

Publication

Lessieur et al., 2017 - The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival

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Fig. 10

Human AHI1 RNA rescues ahi1^lri46 mutant phenotype. (A–D) Whole-mount immunolabeling of pronephric cilia with anti-acetylated tubulin (green) at 36 hpf. Cilia are seen in pronephric ducts of wild-type animals and in ahi1^lri46 mutants following injection of mRNA encoding human AHI1 ([A, C]; arrows). Motor neurons also stained with acetylated tubulin ([B], arrowheads). (E) Quantification of cilia numbers in the distal pronephric duct of ahi1^lri46 mutants following injection. Distal pronephric cilia in wild-type animals were too numerous to count and are not presented graphically. (F–I) Images of 5 dpf retinas stained with PNA (red) and DAPI (blue) to label cone outer segments. (J) Quantification of cone outer segment lengths (n = 6). Scale bar: 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.