ZFIN ID: ZDB-FIG-170227-4
Lessieur et al., 2017 - The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival. Investigative ophthalmology & visual science   58:448-460 Full text @ Invest. Ophthalmol. Vis. Sci.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Days 45-89 to Adult

Fig. 4

Histologic survey of retinas from wild-type and ahi1lri46 adults. (A–C) Dorsal and (D–F) ventral views of toluidine blue–stained 1-μm thick sections of wild-type, 3- and 5-month-old ahi1lri46 mutants. In the dorsal retina, fewer outer segments of UV-sensitive cones (black arrows) and thinning in the ONL (white arrows) was observed at 5 months of age. POS, photoreceptor outer segments; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar: 50 μm.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ahi1lri46/lri46 standard conditions Days 45-89 retinal outer nuclear layer thickness, normal
Days 45-89 retinal rod cell has normal numbers of parts of type retinal rod cell photoreceptor outer segment, normal
Days 45-89 retinal rod cell photoreceptor cell outer segment organization process quality, normal
Adult photoreceptor outer segment layer dorsal region malformed, abnormal
Adult photoreceptor outer segment layer ventral region morphology, normal
Adult retinal cone cell has fewer parts of type retinal cone cell photoreceptor outer segment, abnormal
Adult retinal cone cell photoreceptor cell outer segment organization decreased process quality, abnormal
Adult retinal outer nuclear layer dorsal region decreased thickness, abnormal
Adult retinal outer nuclear layer ventral region thickness, normal
Adult retinal rod cell has normal numbers of parts of type retinal rod cell photoreceptor outer segment, normal
Adult retinal rod cell photoreceptor cell outer segment organization process quality, normal
Acknowledgments:
ZFIN wishes to thank the journal Investigative ophthalmology & visual science for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Invest. Ophthalmol. Vis. Sci.