ZFIN ID: ZDB-FIG-170227-3
Lessieur et al., 2017 - The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival. Investigative ophthalmology & visual science   58:448-460 Full text @ Invest. Ophthalmol. Vis. Sci.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 3

Histologic survey of retinas of 5 dpf wild-type and ahi1lri46 larvae (A–D) Transverse sections of 5 dpf wild-type and ahi1lri46 eyes. Photoreceptor outer segments (arrowheads) were shorter and less organized in ahi1lri46 mutants. (E–H) Sagittal sections of wild-type and ahi1lri46 eyes, taken at the posterior pole just dorsal to the optic nerve (*). Indicated regions (white dashed boxes) in (E, F) are shown at higher magnification in (G, H). Black arrows indicate the larger caliber, more proximal UV cone outer segments. White arrows indicate the smaller caliber, more distal red, green, and blue cone outer segments. R, rod outer segments. Scale bars: 50 μm (A, B), 10 μm (C, D, G, H) and 25 μm (E, F).

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ahi1lri46/lri46 standard conditions Day 5 retinal cone cell development decreased process quality, abnormal
Day 5 retinal cone cell photoreceptor cell outer segment organization decreased process quality, abnormal
Day 5 retinal cone cell photoreceptor outer segment decreased length, abnormal
Day 5 retinal cone cell photoreceptor outer segment disorganized, abnormal
Day 5 retinal cone cell photoreceptor outer segment irregular spatial pattern, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Investigative ophthalmology & visual science for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Invest. Ophthalmol. Vis. Sci.